Results 81 to 90 of about 299,641 (309)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Early medieval war-flails (kistens) from Polish lands

open access: yesFasciculi Archaeologiae Historicae, 2008
...
Piotr N. Kotowicz
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

След края – ранновизантийско и средновековно присъствие в църква Extra Muros до крепостта Бузово кале, Казанлъшко

open access: yesПриноси към българската археология, 2018
The article presents the results of the archaeological excavations at an extra muros church, situated on the northern slope of the Sarnena Gora Mountain, not far from the village of Buzovgrad, Kazanlak region (Figs. 1–3). Built in the early 6th century,
Deyan Rabovyanov   +2 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

International Learning Partnership: Living History and Adult Education in the Museum

open access: yesEXARC Journal, 2012
Many archaeological open-air museums and museums with indoor reconstructions choose to interpret history using the method of ‘living history’, or re-enactments. If one only counts the German references, there is wide variety of terms used by museums when
Susanne Wiermann
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Emotion, violence, vengeance and law in the Middle Ages : essays in honour of William Ian Miller /

open access: yes, 2018
Emotion, violence, vengeance, and law in Medieval Historical Sources -- Hot anger and just indignation: Justificatory strategies in Early Modern German homicide trials / Susanne Pohl-Zucker -- Trial by ordeal by jury in Medieval England, or Saints and ...
Gilbert, Kate,edt   +1 more
core  

Desiring the east: a comparative study of Middle English romance and modern popular sheikh romance [PDF]

open access: yes, 2012
This thesis comparatively examines a selection of twenty-first century sheikh romances and Middle English romances from the fourteenth and fifteenth centuries that imagine an erotic relationship occurring between east and west.
Burge, Amy
core  

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