Results 91 to 100 of about 1,361,869 (313)
History of the Middle Ages. Workshop. Part I. [PDF]
, 2016 Практикум призначається для забезпечення навчального процесу з дисципліни «Історія середніх віків» у вищих навчальних закладах. Практикум розроблено згідно з навчальною програмою для студентів історичних факультетів, яка передбачає вивчення розвитку ...
Салата, Оксана Олексіївна
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
International Learning Partnership: Living History and Adult Education in the Museum
EXARC Journal, 2012 Many archaeological open-air museums and museums with indoor reconstructions choose to interpret history using the method of ‘living history’, or re-enactments. If one only counts the German references, there is wide variety of terms used by museums when
Susanne Wiermann
doaj
Means or end? On the Valuation of Logic Diagrams [PDF]
, 2016 From the beginning of the 16th century to the end of the 18th century, there were not less than ten philosophers who focused extensively on Venn’s ostensible analytical diagrams, as noted by modern historians of logic (Venn, Gardner, Baron, Coumet et al.)
Lemanski, Jens
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Early Indicators of Later Work Levels, Disease, and Death [PDF]
This paper summarizes a collaborative project designed to create a public-use tape suitable for a prospective study of aging among a random sample of 39,616 men mustered into 331 companies of the Union Army.
Larry T. Wimmer, Robert W. Fogel
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The history of Gozo from the early middle ages to modern time [PDF]
, 1990 Though hardly twenty six square miles in area, the little island of Gozo, some four miles to the north-west of Malta, has its own particular history to boast of, parallel to that of Malta and that of Sicily but not so identical that it has not had its
Wettinger, Godfrey
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source