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Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Изображение на танц от Велики Преслав
The article presents a fragment of a pitcher unearthed in 2010 near the Royal Church of Veliki Preslav. It is made of fine clay fired to gray; the surface is coated with green glaze and decorated with incised ornaments and two plastic representations: a
Mariya Manolova-Voykova
doaj
The Preventive Check in Medieval and Pre-industrial England [PDF]
England’s post-Reformation demographic regime has been characterized as ‘low pressure’. Yet the evidence hitherto for the presence of a preventive check, defined as the short-run response of marriage and births to variations in living standards, is ...
Cormac Ó Gráda, Morgan Kelly
core
The research carried out in 2009 in the multicultural site Gnidavs'ka Gìrka near Łuck [PDF]
У статті проаналізовано результати досліджень на багатошаровому поселенні Гнідавська Гірка с.Рованці: на площі 636,5 кв.м. виявлено і досліджено 50 археологічних об'єктів від епохи неоліту до пізнього середньовіччяThe article presents the effects of the ...
Bardetskyi, Andrii +3 more
core
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Childhood Type II Diabetes: The Risks and Complications [PDF]
Type II Diabetes Mellitus is an endocrine disorder that affects people of all ages. Type II Diabetes was once considered adult-onset diabetes, as it was nearly exclusively diagnosed in adults. Over the last three decades, the number of children diagnosed
Kapke, Danielle R
core +1 more source
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source

