Results 111 to 120 of about 299,641 (309)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Prophecy, prophets and the problem of truth in Latin late Antiquity and the early Middle Ages

open access: yes, 2020
Between the 4th and 9th century AC, many Latin Christian thinkers explore the nature and possible definitions of ‘prophecy’ from a philosophical point of view.
Renato de Filippis
core  

Constructing Stage-Environment Fit: Early Adolescents' Psychological Development and their Attitudes Towards School in English Middle and Secondary School Environments

open access: yes, 2010
This longitudinal multiple methods study used an ethnographic approach to examine the development of early adolescents’ psychology during pubertal and school transitions.

core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Davies (Wendy). Wales in the Early Middle Ages.

open access: yes, 1990
Fryde E. B. Davies (Wendy). Wales in the Early Middle Ages. . In: Revue belge de philologie et d'histoire, tome 68, fasc. 4, 1990. Histoire - Geschiedenis. pp.
Fryde, Edmund
core  

Vertèbres d’un ange de mer

open access: yesArchéopages, 2023
Stéphane Augry
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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