Results 101 to 110 of about 299,641 (309)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Texts and contexts : women's dedicated life from Caesarius to Benedict
, 2006 The history of western monasticism in the early middle ages has traditionally been viewed as a continuous process of development. Women religious have been excluded from this discourse, although early work which ‘rediscovered’ female communities has been
Lindsay Rudge, Rudge, Lindsay
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The early development of the cult of St Katherine of Alexandria with particular reference to England
, 2003 PhDSt Katherine of Alexandria, traditionally martyred c. 305, became one of the most popular saints of the later Middle Ages. Whilst most modem studies concentrate on the period of the cult's greatest popularity in the fourteenth and fifteenth ...
Walsh, Christine Louise
core
Savage Dreams: Militant Masculinity between Antiquity and the Middle Ages
, 2023 The article explores the transformation of aristocratic male roles and identity between late Antiquity and the early Middle Ages focusing of literary and material ...
borri
core
Experimental Analysis of Metal Points from Quattro Macine: Reproduction and Interpretation
EXARC Journal, 2019 This paper relates to a study of experimental archaeology, executed by Ruben Cataldo, about the forging methods used to produce some replicas of two metal points found during the archaeological excavations carried out between 1992 and 1996 by the ...
Ruben Cataldo
doaj
An Agglomeration of Early Middle Ages: Meda'in
, 2014 The group of the cities of Meda'in, the administrative capital of the Sassanid Empire from the early Middle Ages to the collapse of this empire, is one of the biggest metropolises of the antiquity and of the Middle Ages. The group of the cities of Meda'in, consisting of many cities and towns built in different sizes and various times, has a diverse ...
Bakir, Abdulhalik, Altungök, Ahmet
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source