Results 51 to 60 of about 11,933,129 (302)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Early Modern Genres of History [PDF]
Bringing together an international group of literary scholars, intellectual historians, and cultural historians, this book discusses history in its various forms, either as texts or images in the early modern period (1500–1800).
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Catacomb Rediscoveries in the Central Mediterranean (16th–20th Century): An Overview
HistoriesThis article focuses on the rediscovery of catacombs in the central Mediterranean and explores some of this historiographic heritage through different kinds of documents in order to present some interesting results regarding human and cultural ...
Chiara Cecalupo
doaj +1 more source
Motiv posta i molitve u hrvatskoglagoljskim tekstovima 15. i 16. stoljeća
Diacovensia, 2019 The Croatian Glagolitic medieval literature consisted mostly of religious texts (e.g. hagiographies, visions, debates/contrasts, Miracles of the Blessed Virgin, dialogue poems, miracle and morality plays).
Marija-Ana Dürrigl
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Vrcholnostredoveký hrad Peťuša
Archaeologia Historica, 2017 Cieľom článku je predstaviť vedeckej verejnosti výskum a zistené poznatky o zaniknutom hrade Peťuša a polemizovať o jeho postmedieválnom využívaní. Vrcholno- a neskorostredoveký hrad oválneho pôdorysu (40 × 20 m) sa nachádza pri Zvolene vo vizuálnej ...
Noémi Beljak Pažinová
doaj +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Honour and Fighting Social Advancement in the Early Modern Age
Acta Periodica Duellatorum, 2015 The article considers the importance of military service in social advancement, here understood as filling the role of “prince” in feudal law and thus participating in the government of an estate, in the transition from the Late Middle Ages to the ...
Gassmann Jürg
doaj +3 more sources
A Dental Prosthesis from the Early Modern Age in Tuscany (Italy) [PDF]
Clinical Implant Dentistry and Related Research, 2016 AbstractBackgroundDuring archaeological excavation, carried out in the S. Francesco Monastery at Lucca (Tuscany, Italy), a golden dental appliance was discovered. The prosthesis was found, together with commingled human remains, in the collective tomb of the aristocratic family of the Guinigi, a powerful family who governed Lucca from 1392 until 1429 ...
Minozzi, Simona +3 more
openaire +3 more sources