Results 41 to 50 of about 11,933,129 (302)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Model of female friendship in early modern and modern age

open access: yes, 2017
My paper is divided into three parts. The first part revolves around an article by Penelope Anderson and wonders about the absence of female friends in friendship studies on early modern and modern age.
A. Ceron
core   +2 more sources

Women’s Account Books in Venice and the Veneto Region. Material and Emotional Aspects

open access: yesCahiers d’Études Italiennes
In recent years, several studies have focused on women’s everyday writings in the early modern period, highlighting, even in the Italian context, the specific circumstances and the skills with which women of the past engaged in writing and accounting in ...
Maria Adank
doaj   +1 more source

Výskum hradu Dobrá Niva v rokoch 2013 a 2014

open access: yesArchaeologia Historica, 2015
Cieľom príspevku je predstaviť a interpretovať nálezovú situáciu na NKP Hrad Dobrá Niva v katastrálnom území obce Podzámčok, okres Zvolen. Archeologický výskum uskutočnený v rokoch 2013 a 2014 priniesol nové informácie o vrcholno- a neskorostredovekom až
Noémi Beljak Pažinová   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

On “shapelings” and “childlings”: a linguistics approach to the emergence of new cultural borders between the unborn and the new-born child in EME (1500-1700)

open access: yesJournal of English Studies, 2020
This contribution aims at exploring the emergence of early-age stereotypes in Early Modern England from a Cultural Linguistics approach to Age Studies, using the Historical Thesaurus of the Oxford English Dictionary as a corpus.
Paloma Tejada-Caller
doaj   +1 more source

Croatia and Slavonia in The Early Modern Age [PDF]

open access: yesHungarian Studies, 2013
Slavonia and Croatia belonged to the Habsburg controlled part of the Kingdom of Hungary. As a result of the Ottoman conquest, the two provinces merged into a single territorial entity, and this study discusses this process. The noble society and the public administration of Croatia and Slavonia had fewer and fewer links with the Hungarian institutions ...
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ROYAL POWER SACRALIZATION IN THE MIDDLE AGES AND EARLY MODERN AGE AS STUDIED BY DOMESTIC HISTORIANS IN XX – EARLY XXI CENTURY

open access: yesВестник Кемеровского государственного университета, 2018
The author analyzes the main stages of the research process conducted by domestic historians in the sphere of the European  rulers’ power sacralization in the Middle Ages and early Modern Age.
E. N. Deniskevich
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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