Results 71 to 80 of about 1,658,969 (302)

Early school-leaving in the Netherlands [PDF]

The role of student-, family- and school factors for early school-leaving in lower secondary educationMost studies on early school-leaving address only partial causes of why some students leave school early.
Traag Tanja, Velden Rolf K.W. van der
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Social Bonding, Early School Leaving, and Delinquency [PDF]

In this paper we investigate how successful social bonding theory is at predicting juvenile delinquency and school dropout behaviour. We adopt a simple dynamic approach which assumes that past involvement in risky behaviour reduces individual restraints ...
Marie Olivier, Traag Tanja, Velden Rolf van der   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The silent face of school dropout: When school loses its meaning

Encyclopaideia
The phenomenon of early school leaving has worrying dimensions in Italy, both in its explicit (according to recent ISTAT data from 2023 on Early Leaving From Education And Training) and implicit form (as shown by the latest INVALSI Report of 2024 ...
Antonella Arioli
doaj   +1 more source

Do Dads matter? Or is it just their money that matters? Unpicking the effects of separation on educational outcomes by and [PDF]

The widely held view that separation has adverse effects on children has been the basis of important policy interventions. While a small number of analyses have been concerned with selection into divorce, no studies have attempted to separate out the ...
Ian Walker, Yu Zhu
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Programs and actions against early school leaving: cases and evaluation methods

Formare, 2016
This paper explores the topic of early school leaving and stresses its importance in the inclusive education. A synthetic review of literature is explained, paying specific attention to evaluation results of interventions realized.
Luisa Pandolfi
doaj   +1 more source

Family factors in early school leaving [PDF]

Young people who leave school early are at greater risk of experiencing long-term unemployment and slipping into social exclusion as a result. This paper looks at the risk factors associated with young people exiting the education system prematurely,
Elly Robinson, Veronica Meredith
core