Results 91 to 100 of about 1,807,819 (311)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Jewish Community of Irkutsk in 1917 - the Late 1930s

RUDN Journal of Russian History
The authors examine the history of the early Soviet period (1917 - late 1930s) of the Jewish community of Irkutsk, which by the beginning of the 20th century was the largest Jewish community in Siberia. The fate of the main choral synagogue, three houses
Elena A. Berman, Elena S. Genina
doaj   +1 more source

Building Citywide Systems for Quality: A Guide and Case Studies for Afterschool Leaders [PDF]

, 2012
This guide is intended to help cities strengthen and sustain quality afterschool programs by using an emerging practice known as a quality improvement system (QIS). The guide explains how to start building a QIS or how to further develop existing efforts
Alicia Wilson-Ahlstrom, Charles Smith, Elizabeth Devaney, Nicole Yohalem   +3 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Crystal Eastman and the Internationalist Beginnings of American Civil Liberties [PDF]

, 2004
The modern American civil liberties movement famously began with the United States\u27s intervention in World War I. Yet these beginnings have long raised a conundrum for civil liberties historians.
Witt, John Fabian
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

MORALE AND DISCIPLINE OF THE SOVIET POLICE OFFICERS IN THE LATE 1940s – EARLY 1950s (on archival materials of the Sverdlovsk region)

Электронное приложение к Российскому юридическому журналу, 2019
The article is based on unpublished archival materials of the Center for Documentation of Public Organizations of the Sverdlovsk Region. The author examines the internal state of the Soviet police in the post-war period.
Mamyachenkov Vladimir
doaj   +1 more source

The Directions of Educational Activities of Polish Organizations in West Prussia in the Late Nineteenth and Early Twentieth Century

Studia Paedagogica Ignatiana, 2016
The development of the Polish national movement in West Prussia began with the Spring of Nations. In the face of the Germanization policy of the authorities, Prussian Poles began to create their own organizations designed to maintain Polish identity and ...
Paweł Śpica
doaj   +1 more source

Morphofunctional state of the immune system organs in hypotrophic piglets in the early neonatal period

Agrarian Bulletin of the Urals
Abstract. The purpose of the study was to study the state of the immune system organs in hypotrophic piglets in the early neonatal period in an industrial pig breeding complex. Methods. The experiment was conducted in 2023 in a large industrial pig farm in the Voronezh region on piglets of the wounded neonatal period received from sows 3-4 farrowing ...
B. V. Shabunin, A. V. Nekrasov, E. M. Stepanov, E. V. Mikhaylov   +3 more
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source