Results 141 to 150 of about 1,814,700 (309)

United Kingdom: changing political opportunity structures, policy success and continuing challenges for lesbian, gay and bisexual movements [PDF]

, 2011
No abstract ...
Kollman, K., Waites, M.
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

What's Going on in Community Media [PDF]

, 2007
What's Going On in Community Media shines a spotlight on media practices that increase citizen participation in media production, governance, and policy.
Fred Johnson, Karen Menichelli
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Pioneers of Biodynamics in USA: The Early Milestones of Organic Agriculture in the United States

, 2019
{"references": ["Northbourne, Lord, Look to the Land. 1940, London: Dent.", "Paull, J., Lord Northbourne, the man who invented organic farming, a biography. Journal of Organic Systems, 2014. 9 (1): p. 31-53.", "Carson, R., Silent Spring. Readers Union 1964 members' ed. 1962, London: Hamish Hamilton", "Paull, J., The Rachel Carson letters and the making
openaire   +2 more sources

Building Stronger Nonprofits Through Better Financial Management [PDF]

, 2012
The Wallace Foundation's four-year Strengthening Financial Management in Out-of-School Time initiative(SFM) was designed to improve the financial management systems of 26 well-respected Chicago nonprofits that provide out-of-school-time (OST) services ...
Lauren J. Kotloff, Nancy Burd
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A high-resolution late Paleocene–early Eocene organic-walled dinoflagellate cyst zonation of the United States Atlantic Coastal Plain

Journal of Micropalaeontology
Abstract. Over the past decades, many expanded sedimentary records from the US Atlantic Coastal Plain (ACP) have been studied in detail to assess causes and consequences of the Paleocene–Eocene Thermal Maximum (PETM; ∼ 56 Ma). In ACP sections, the PETM, which is globally marked by a distinct negative carbon isotope excursion (CIE) lasting ∼ 180 kyr ...
Mei Nelissen, Appy Sluijs, Debra A. Willard, Henk Brinkhuis   +3 more
openaire   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source