Results 141 to 150 of about 1,807,819 (311)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Faith-Based Charity and Crowd Out during the Great Depression [PDF]

Interest in religious organizations as providers of social services has increased dramatically in recent years. Churches in the U.S. were a crucial provider of social services through the early part of the twentieth century, but their role shrank ...
Daniel M. Hungerman, Jonathan Gruber
core  

Better Choices: Charter Incubation as a Strategy for Improving the Charter School Sector [PDF]

, 2011
The twenty years since Minnesota passed the nation's first charter school law have seen a great expansion in school choice, with charters operating in all but ten states and enrolling nearly two million students nationwide.
Joe Ableidinger, Julie Kowal
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The Pioneers of Biodynamics in USA: The Early Milestones of Organic Agriculture in the United States

, 2019
{"references": ["Northbourne, Lord, Look to the Land. 1940, London: Dent.", "Paull, J., Lord Northbourne, the man who invented organic farming, a biography. Journal of Organic Systems, 2014. 9 (1): p. 31-53.", "Carson, R., Silent Spring. Readers Union 1964 members' ed. 1962, London: Hamish Hamilton", "Paull, J., The Rachel Carson letters and the making
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Alaska Civic Learning Assessment Project: Final Report and Policy Brief [PDF]

, 2006
In late 2002, the Center for Information and Research on Civic Learning and Engagement (CIRCLE) and Carnegie Corporation of New York, in consultation with the Corporation for National and Community Service, convened a series of meetings involving some
Fickel, Letitia, Hill, Alexandra, Hirshberg, Diane   +2 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A high-resolution late Paleocene–early Eocene organic-walled dinoflagellate cyst zonation of the United States Atlantic Coastal Plain

Journal of Micropalaeontology
Abstract. Over the past decades, many expanded sedimentary records from the US Atlantic Coastal Plain (ACP) have been studied in detail to assess causes and consequences of the Paleocene–Eocene Thermal Maximum (PETM; ∼ 56 Ma). In ACP sections, the PETM, which is globally marked by a distinct negative carbon isotope excursion (CIE) lasting ∼ 180 kyr ...
Mei Nelissen, Appy Sluijs, Debra A. Willard, Henk Brinkhuis   +3 more
openaire   +2 more sources

Fusing Arts, Culture and Social Change: High Impact Strategies for Philanthropy [PDF]

, 2011
Examines the role of the arts in engaging, educating, and building communities and addressing social, economic, environmental, and other injustices.
Holly Sidford
core