Results 161 to 170 of about 22,736,691 (304)

Manufactured Ambiguity: The Blurred Line Between Formal and Informal Authority in Lyari, Karachi

South Asia Multidisciplinary Academic Journal
Lyari, one of the oldest settlements in Karachi, has been the site of conflict between political parties, criminal gangs, and law enforcement agencies since the early 2000s.
Nida Kirmani
doaj  

Involuntary retirement and organizational climates: a multilevel study of older workers. [PDF]

J Gerontol B Psychol Sci Soc Sci
Marabini C, Henkens K, van Solinge H.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Clinical Issues - August 2026. [PDF]

AORN J
Hanks T.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

New electronic state documents list -February 2024

The monthly New South Carolina State Documents publication by the State Library provides a list of state documents published by state agencies that have been cataloged and added to the South Carolina State Documents Depository.
South Carolina State Library
core  

A Perspective on Covalent Hit Identification and Validation in the European Pharmaceutical Industry. [PDF]

Chembiochem
Schadt O, Essig S, Testolin G.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Safeguarding in dance as a public health issue: a systems-level policy framework. [PDF]

Front Public Health
Cumming J, Quinton ML.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source