Results 41 to 50 of about 126,989 (260)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Knowledge, attitudes, and practices about dengue fever among the population in Hodeidah, Yemen

Scientific Reports
In Yemen, dengue is one of the major public health concerns. Cases have been recorded in almost all governorates in Yemen. In 2019, the Hodeidah governorate had the second highest death rate in the country.
Mohammed Ahamed Hajjam, Ahlam Bin Briek
doaj   +1 more source

Design and Application of Risk Early Warning System for Subway Station Construction Based on Building Information Modeling Real-Time Model

Advances in Civil Engineering, 2021
The problems faced by subway stations in the construction process are more complex than those by overground buildings. Therefore, the construction risk for such structures is highly unpredictable and the risk management is difficult. Building information
Qianlong Tang, Mingfeng Lei, Binbin Zhu, Limin Peng, Weimin Wu, Chenghua Shi   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Exploring Urban Vitality Characteristics and Interactive Mechanisms at the Community Scale through the Lens of Human Behaviour: A Case Study of Chongqing, China [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Exploring urban vitality characteristics and interactive mechanisms are helpful for formulating policy, advancing urban planning and promoting sustainable development.
J. Sheng, J. Sheng, Y. He, T. Lu, T. Lu, F. Wang, F. Wang, Y. Huang, B. Leng, X. Zhang, Y. Chen   +10 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

High-Precision Imaging and Dense Vehicle Target Detection Method for Airborne Single-Pass Circular Synthetic Aperture Radar

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Circular synthetic aperture radar (CSAR) has advantages of the omnidirectional detection and high-resolution imaging. However, when CSAR detects the dense target in the observation scene, the phenomena such as the layover effect in the CSAR image may ...
Haozong Liu, Hongtu Xie, Ting Gao, Shiliang Yi, Yuanjie Zhang   +4 more
doaj   +1 more source

Implementing Obstetric Early Warning Systems [PDF]

American Journal of Perinatology Reports, 2018
AbstractSevere maternal morbidity and mortality are often preventable and obstetric early warning systems that alert care providers of potential impending critical illness may improve maternal safety. While literature on outcomes and test characteristics of maternal early warning systems is evolving, there is limited guidance on implementation.
Alexander M. Friedman, Mary L. Campbell, Carolyn R. Kline, Suzanne Wiesner, Mary E. D'Alton, Laurence E. Shields   +5 more
openaire   +3 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Discussion on early warning method of coal and gas outburst

Gong-kuang zidonghua, 2018
Definition of early warning of coal and gas outburst was given, and difference between the early warning and forecasting was clearly pointed out. The early warning of coal and gas outburst was classified from angle of space, time and index system, and ...
ZHAO Xusheng, NING Xiaoliang, ZHANG Qinghua, MA Guolong   +3 more
doaj   +1 more source