Results 41 to 50 of about 96,718 (306)

Endocrine disruptors and antimicrobial agents in an intercity study in England: Towards holistic environmental and public exposure assessment using water-based epidemiology and retrospective mass spectra data mining

Environment International
An analytical framework was developed, allowing for suspect screening and retrospective quantification of hazardous household-derived chemicals (HDCs) in community wastewater and river water to assess public exposure and environmental health status.
Eva Hawkins, Megan Robertson, John Bagnall, Barbara Kasprzyk-Hordern   +3 more
doaj   +1 more source

Rangeland water requirement satisfaction index under rainfall variability and predicting future rainfall scenarios: implication for availability of feed resources

Ecological Processes, 2017
Introduction Rangeland ecosystems provide multiple ecosystem services, including feed resources for wild and domestic herbivores in semi-arid areas.
Hassen M. Ahmed, Zewdu K. Tessema, Adugna Tolera, Diriba Korecha   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Early detection of ecosystem regime shifts: A multiple method evaluation for management application [PDF]

, 2012
Critical transitions between alternative stable states have been shown to occur across an array of complex systems. While our ability to identify abrupt regime shifts in natural ecosystems has improved, detection of potential early-warning signals ...
Christian Möllmann (152854), Otto, Saskia, Gardmark, A., Joachim P Gröger, Georgs Kornilovs, Otto, Saskia A., Moellmann, Christian, Dakos, Vasilis, Anna Gårdmark (152842), Otto Saskia A., Thrush, Simon, Groger, J.P., Dakos, V., Dakos Vasilis, Vasilis Dakos, Saskia A. Otto (152850), Groeger, Joachim P, Kornilovs, G., Georgs Kornilovs (152846), Groeger, Joachim P., Kornilovs Georgs, Möllmann Christian, Vasilis Dakos (150752), Lindegren Martin, Lindegren, Martin, Gardmark, Anna, Lindegren, M., Christian Möllmann, Joachim P. Gröger (152838), Gröger Joachim P., Mollmann, C., Martin Lindegren, Kornilovs, Georgs, Saskia A Otto, Gårdmark Anna, Otto, S.A., Martin Lindegren (127611), Gröger, Joachim, Anna Gårdmark, Möllmann, Christian   +39 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Consideration of cost-efficient early warning system utilizing existing analogue radio broadcasting in Indonesia

MATEC Web of Conferences, 2018
Early warning systems can increase disaster management capacity. Indonesia worked out the national development policy direction of 2015 – 2019 containing establishment of early warning systems.
Kamei Masashi, Gingging Rahadian, Dinga Ariza, Winata Widi   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Preliminary discussion on the earthquake early warning network of Jiangxi Province

地震科学进展, 2021
The earthquake early warning system is formed by seismic stations and the urgent information systems. Many seismic stations are added to the original seismic monitoring network and old operation systems are upgraded.
Si Yu, Tingting Tang
doaj   +1 more source