Results 71 to 80 of about 14,110,747 (283)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level

Nature Communications
Monitoring enzyme structural dynamics is essential for elucidating catalytic mechanisms, yet transient conformational fluctuations on microsecond-to-millisecond timescales remain challenging to resolve with conventional techniques.
Zhimin Fan, Zusen Chen, Zhengwen Gong, Sanjun Shi, Mingdi Xu, Xiaonan Feng, Yulu Liu, Ya Hu, Xiaoduo Chen, Guomao Zheng, Bintian Zhang   +10 more
doaj   +1 more source

Automatic early warning systems for the environment [PDF]

Nuclear Technology and Radiation Protection, 2003
Computerized, continuous monitoring environmental early warning systems are complex networks that merge measurements with the information technology. Accuracy, consistency, reliability and data quality are their most important features.
Lesjak Martin
doaj   +1 more source

SNEWS: The supernova early warning system [PDF]

AIP Conference Proceedings, 2000
World-wide, several detectors currently running or nearing completion are sensitive to a prompt core collapse supernova neutrino signal in the Galaxy. The SNEWS system will be able to provide a robust early warning of a supernova's occurrence to the astronomical community using a coincidence of neutrino signals around the world. This talk describes the
openaire   +2 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Inclusive early warning early action: Checklist and implementation guide [PDF]

, 2023
The checklist and implementation guide for inclusive early warning and early action was developed as part of the Climate Risk and Early Warning Systems (CREWS) Pacific initiative and seeks to contribute to the implementation of the Executive Action Plan ...
Kelman, Ilan, Fearnley, Carina
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

AN EARLY WARNING SYSTEM FOR FLOUNDER DISEASE [PDF]

, 2009
With the constant expansion of the scale and mismanagement in aquaculture,the diseases of flounder occur more and more frequently than before, which has brought great economic losses to fish farmers. For the sake of the problem described above, based on a great number of surveys, the early warning theory of flounder disease, the analysis of the ...
Bin Xing, Daoliang Li, Jianqin Wang, Qingling Duan, Jiwen Wen   +4 more
openaire   +1 more source