Results 41 to 50 of about 744,259 (311)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Fields, Funerals and Furnaces: On the Use of Fire during the Pre-Roman Iron Age on the Island of Gotland

open access: yesCurrent Swedish Archaeology, 2005
By studying the material culture of the island of Gotland, one can conclude that the use of fire was integrated into the lives of the Pre-Roman people. Agricultural land was cleared by fire and cremation was a part of the burial tradition.
Anna Arnberg
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Validity and Reliability Study of Science-Edutainment Interactive Multimedia on Earth Topic for the 7th Graders of Junior High Schools

open access: yesJurnal Penelitian Fisika dan Aplikasinya, 2018
Natural science, as a fundamental science, requires a series of observations to be understood. For the subject about structure of earth, earthquake, and volcano, the students need the direct observation because the nature of the subject that tends to be ...
Mahmudah Mahmudah   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Earth Felt the Wound: The Affective Divide

open access: yesIdentities, 2011
Author(s): Claire Colebrook Title (English): Earth Felt the Wound: The Affective Divide Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 8, No.
Claire Colebrook
doaj  

Salt for the earthen oven revisited

open access: yesHTS Teologiese Studies/Theological Studies, 2011
The symbolic interpretation of the salt sayings in the New Testament (Mt 5:13; Mk 9:42–50; Lk 12:49–53; 14:34–35) is best based on the long-standing cultural practice of using salt as a catalytic agent to burn dung, the common fuel for the typical ...
John J. Pilch
doaj   +1 more source

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