Results 41 to 50 of about 301,374 (236)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The birth of spacetime atoms as the passage of time

, 2014
The view that the passage of time is physical finds expression in the classical sequential growth models of Rideout and Sorkin in which a discrete spacetime grows by the partially ordered accretion of new spacetime atoms.Comment: Article based on an ...
Dowker, Fay
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A bound-constrained formulation for complex solution phase minimization [PDF]

Geoscientific Model Development
Prediction of mineral phase assemblages is essential to better understand the dynamics of the solid Earth, such as metamorphic processes, magmatism and the formation of mineral ore deposits.
N. Riel, N. Riel, B. J. P. Kaus, B. J. P. Kaus, B. J. P. Kaus, A. de Montserrat, E. Moulas, E. Moulas, E. Moulas, E. C. R. Green, H. Dominguez   +10 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Gravitomagnetism and gravitational waves

, 2010
After extensively reviewing general relativistic gravitomagnetism, both historically and phenomenologically, we review in detail the so-called magnetic components of gravitational waves (GWs), which have to be taken into account in the context of the ...
Corda, Christian, Iorio, Lorenzo
core   +1 more source

Super Earth Explorer: A Coronagraphic Off-Axis Space Telescope [PDF]

, 2008
The Super-Earth Explorer is an Off-Axis Space Telescope (SEE-COAST) designed for high contrast imaging. Its scientific objective is to make the physico-chemical characterization of exoplanets possibly down to 2 Earth radii >.
A. Aylward, A. Boccaletti, A. Boccaletti, A. Léger, A. Wolszczan, B. McIntosh, B. Sato, C.-U. Keller, C.U. Keller, Ch. Sotin, D. Mawet, D. Mawet, D. Mawet, D. Rouan, D. Stam, D. Stam, D. Valencia, E. Ford, E. Palle, E. Rivera, E. Williams, G. Perrin, G. Tinetti, G. Tinetti, J. Fortney, J. Fortney, J. Hough, J. Kemp, J. Schneider, J. Trauger, J. Trauger, J. Y-K. Cho, J.-L. Beuzit, J.-Ph. Beauliau, M. Kuchner, M. Kuchner, M. Marley, M. Swain, O. Guyon, P. Baudoz, P. Baudoz, P. Baudoz, R. Doyon, R. Soummer, S. Ida, S. Seager, S. Udry, S. Udry, W. Benz, W. Traub   +49 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Subluminal OPERA Neutrinos

, 2011
The OPERA collaboration has announced to have observed superluminal neutrinos with a mean energy 17.5 GeV, but afterward the superluminal interpretation of the OPERA results has been refuted theoretically by Cherenkov-like radiation and pion decay.
Einstein A., Einstein A., Frank P., Frank P., ICHIRO ODA, Ignatowsky W. V., Ignatowsky W. V., Jackson J. D., Weinberg S.   +8 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source