Results 41 to 50 of about 282,573 (230)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Tidal instability in a rotating and differentially heated ellipsoidal shell

, 2010
The stability of a rotating flow in a triaxial ellipsoidal shell with an imposed temperature difference between inner and outer boundaries is studied numerically.
Aldridge, Aurnou, Christensen, Cébron, D. Cébron, Fabijonas, Goodman, Herreman, Hindmarsh, Kerswell, Kerswell, Kerswell, King, Kumazawa, Lacaze, Lacaze, Le Bars, Le Bars, Le Bars, Le Dizès, Leweke, Lister, Lubow, M. Le Bars, Malkus, Meunier, Moore, P. Maubert, Rieutord, Ryu, Stanley, Sumita, Tilgner, Widnall, Williams   +34 more
core   +3 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Multiscale modeling of ultrafast element-specific magnetization dynamics of ferromagnetic alloys

, 2015
A hierarchical multiscale approach to model the magnetization dynamics of ferromagnetic ran- dom alloys is presented. First-principles calculations of the Heisenberg exchange integrals are linked to atomistic spin models based upon the stochastic Landau ...
Atxitia, U., Carva, K., Chubykalo-Fesenko, O., Hinzke, D., Nieves, P., Nowak, U., Oppeneer, P. M.   +6 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

From The Principle Of Least Action To The Conservation Of Quantum Information In Chemistry: Can One Generalize The Periodic Table? [PDF]

, 2019
The success of a few theories in statistical thermodynamics can be correlated with their selectivity to reality. These are the theories of Boltzmann, Gibbs, end Einstein.
Penchev, Vasil
core  

On the effects of the Dvali-Gabadadze-Porrati braneworld gravity on the orbital motion of a test particle

, 2005
In this paper we explicitly work out the secular perturbations induced on all the Keplerian orbital elements of a test body to order O(e^2) in the eccentricity e by the weak-field long-range modifications of the usual Newton-Einstein gravity due to the ...
Iorio L, Iorio L, Jacobson R A, Jacobson R A, Kaula W M, Lense J, Lorenzo Iorio, Murray C D, Nicolis A, Pitjeva E V Kurtz D W, Roy A E, Rubincam D P, Standish E M   +12 more
core   +1 more source

Orbit Rendezvous Maneuvers in Cislunar Space via Nonlinear Hybrid Predictive Control

Dynamics
The NASA’s Artemis project intends to bring humans back to the Moon in the next decade. A key element of the project will be the Lunar Gateway, a space station placed in a peculiar, near rectilinear Halo orbit in the vicinity of a collinear libration ...
Dario Sanna, David Paolo Madonna, Mauro Pontani, Paolo Gasbarri   +3 more
doaj   +1 more source