Results 51 to 60 of about 3,077,333 (252)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
HeliyonA methodological approach based on rare earth elements analysis was developed to observe human activities in the stratigraphic sequence of Alagankulam.
Thirumalini Selvaraj +7 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
High field strength element systematics and Lu-Hf & Sm-Nd garnet geochronology of orogenic eclogites [PDF]
, 2008 Concerning the Bulk Silicate Earth (BSE), the depleted mantle and the continental crust are thought to balance the budget of refractory and lithophile elements, resulting in complementary trace element patterns.
Schmidt, Alexander
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Calculation of normal mode spectra in laterally heterogeneous earth models using an iterative direct solution method, [PDF]
Normal mode observations play an important role in studying broad-scale lateral variations in the Earth. Such studies require the calculation of accurate synthetic spectra in realistic earth models, and this remains a computationally challenging problem.
Deuss, Arwen +2 more
core +1 more source
Online preconcentration ICP-MS analysis of rare earth elements in seawater [PDF]
, 2012 The rare earth elements (REEs) with their systematically varying properties are powerful tracers of continental inputs, particle scavenging intensity and the oxidation state of seawater.
Stichel, Torben +5 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Advances in Civil EngineeringLocal excavation adjacent to retaining structures causes partial unloading of the backfill, thereby altering the failure mechanism and the magnitude of active earth pressure acting on the structures.
Chen Xu +4 more
doaj +1 more source