Results 91 to 100 of about 6,682,022 (395)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Editorial: Artificial intelligence and machine learning in Earth science
Frontiers in Earth Science, 2023 Sid-Ali Ouadfeul +3 more
doaj +1 more source
Dizhen xuebao地球科学是一门数据密集型学科，而知识图谱则被认为是充分利用和发挥地球科学领域庞大数据的一种有效方式。相对于通用大模型技术的发展，知识图谱能提供更为准确的知识，增强生成式大模型结果的智能性和可靠性。本文首先阐释了知识图谱的相关概念和构建方法；然后，对在科学领域广泛应用的顶层本体基本形式化本体模型进行了详细介绍，简单总结了地球科学领域已经建成的知识图谱，并着重论述了地球科学领域的地质学核心本体和地质科学本体，以及两者的异同；最后，介绍了与地球科学知识图谱构建相关的深时数字地球计划等国际地学数据科学计划 ...
Fenggui Niu, Bei Zhang, Shi Chen
doaj +1 more source
Pre-/Post-Knowledge Assessment of an Earth Science Course for Elementary/Middle School Education Majors [PDF]
, 2002 This article discusses the benefits of experiencing the process of Earth Science through active learning strategies, and how a simple assessment instrument was developed and used to evaluate a specific course in Earth Science for educators.
David Gosselin
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Earth Science Data Analytics: Definitions, Techniques and Skills
Data Science Journal, 2017 The continuous evolution of data management systems affords great opportunities for the enhancement of knowledge and advancement of science research. To capitalize on these opportunities, it is essential to understand and develop methods that enable data
S. Kempler, Tiffany Mathews
semanticscholar +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source