Results 91 to 100 of about 262,952 (308)

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

A multi-hazards earth science perspective on the COVID-19 pandemic: the potential for concurrent and cascading crises. [PDF]

Environ Syst Decis, 2020
Quigley MC, Attanayake J, King A, Prideaux F.   +3 more
europepmc   +1 more source

Cosmology and Confucianism JosephNeedham with the collaboration of WangLing, Science and Civilisation in China, Volume III, “Mathematics and the Sciences of the Heaven and the Earth”, Cambridge University Press, Cambridge, England, 1959, pp. xlvii, 876, Illus., Bibliogs., Index, Table of Dynasties, $22.50. [PDF]

, 1960
J.E. Spencer
openalex   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Adoption of Machine Learning Techniques in Ecology and Earth Science [PDF]

One Ecosystem, 2016
Anne Thessen
doaj   +2 more sources

The impact of elevated CO2 on methanogen abundance and methane emissions in terrestrial ecosystems: A meta-analysis

iScience
Summary: Methane (CH4), one of the major greenhouse gases, plays a pivotal role in global climate change. Elevated CO2 concentration (eCO2) increases soil carbon storage, which may provide a valuable material base for soil methanogenic microorganisms and
Yiwen Ding, Mingyu Wang, Xiaojuan Du, Xue He, Tianle Xu, Xinyu Liu, Fuqiang Song   +6 more
doaj   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Reimagining Earth in the Earth System

Journal of Advances in Modeling Earth Systems
Terrestrial, aquatic, and marine ecosystems regulate climate at local to global scales through exchanges of energy and matter with the atmosphere and assist with climate change mitigation through nature‐based climate solutions.
Gordon B. Bonan, Oliver Lucier, Deborah R. Coen, Adrianna C. Foster, Jacquelyn K. Shuman, Marysa M. Laguë, Abigail L. S. Swann, Danica L. Lombardozzi, William R. Wieder, Kyla M. Dahlin, Adrian V. Rocha, Michael D. SanClements   +11 more
doaj   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Canadian Journal of Earth Sciences, Vol. 3, No. 6, 1966, [i], 737–915 p., illus., 14 maps [in separate folder]. (Obtainable from National Research Council, Ottawa 7, Canada. $2.) [PDF]

, 1967
Walther Hofmann
openalex   +2 more sources