Results 81 to 90 of about 1,830,401 (244)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Life Line - February 2019 [PDF]

open access: yes, 2019
Curricular Changes, Dr. Young\u27s Sabbatical, Coal, Gas & Oil - Geology trip to eastern Ohio, Rebekah Perry is engaging the community in natural history, Student Research, Fem in STEM, Zoo students on Belize Trip, Scientific Arthttps://digitalcommons ...
Otterbein Biology and Earth Science Department,
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

The Algebra of Earth Science [PDF]

open access: yes
In this activity, students will graph carbon dioxide levels against temperature change over time and examine the data to look for trends. Another plotting exercise is provided in which they examine the relationship between the retreat of glaciers and sea

core  

Life Line March 2018 [PDF]

open access: yes, 2018
Welcome Andrew Calinger-Yoak - Outdoor Laboratory - Conservation Biology - Safari in South Africa - Chengdu Panda Base - Mussellshttps://digitalcommons.otterbein.edu/lifeline/1004/thumbnail ...
Otterbein Biology and Earth Science Department,
core   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Electrokinetics in Earth Sciences [PDF]

open access: yesInternational Journal of Geophysics, 2013
Tsuneo Ishido, Laurence Jouniaux
openaire   +3 more sources

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

open access: yesFEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee   +5 more
wiley   +1 more source

Coverpage and Contents [PDF]

open access: yes, 1967
Coverpage and Contents from Volume 2, Number 1, 1968 of Earth Science ...
Waikato Geological Society
core   +7 more sources

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

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