Results 101 to 110 of about 1,466,569 (295)

Opportunities and challenges for people-centered multi-hazard early warning systems: Perspectives from the Global South

iScience
Summary: This perspective critically examines the challenges and opportunities of implementing people-centered multi-hazard early warning systems (MHEWS) in the Global South.
Budimir Mirianna, Šakić Trogrlić Robert, Almeida Cinthia, Arestegui Miguel, Chuquisengo Vásquez Orlando, Cisneros Abel, Cuba Iriarte Monica, Dia Adama, Lizon Leon, Madueño Giorgio, Ndiaye Alioune, Ordoñez Caldas Miluska, Rahman Tamanna, RanaTharu Bikram, Sall Alpha, Uprety Dharam, Anderson Chris, McQuistan Colin   +17 more
doaj   +1 more source

Lidar remote sensing from space: NASA's plans in the Earth sciences [PDF]

, 1986
A multidisciplinary study of the Earth System to provide a better understanding of the complex interrelated processes involved in the system, the Earth Observing System (EOS), is being developed. Capabilities of the Space Station, both the polar orbiting
Curran, R. J.
core   +1 more source

Time-variability in the Interstellar Boundary Conditions of the Heliosphere: Effect of the Solar Journey on the Galactic Cosmic Ray Flux at Earth

, 2011
During the solar journey through galactic space, variations in the physical properties of the surrounding interstellar medium (ISM) modify the heliosphere and modulate the flux of galactic cosmic rays (GCR) at the surface of the Earth, with consequences ...
A. Yeghikyan, B. Wolff, B.E. Wood, C. Heiles, C.P. Sonett, D.M. Meyer, E. Möbius, G. Hebrard, G.P. Zank, H. Müller, H. Müller, H.-R. Müller, Hans-Reinhard Mueller, I.G. Usoskin, J. Goldston Peek, J. Kirkby, J.D. Slavin, J.T. Gosling, K.G. McCracken, K.G. McCracken, L.A. Fisk, M. Salvati, M. Wolleben, M.A.C. Perryman, N.V. Pogorelov, P.C. Frisch, P.C. Frisch, P.C. Frisch, P.C. Frisch, P.C. Frisch, P.C. Frisch, P.C. Frisch, Priscilla C. Frisch, R. Lallement, R. Muscheler, R. Schönrich, R.A. Leske, R.A. Leske, R.A. Mewaldt, R.C. Bohlin, S. Redfield, S. Redfield, S. Redfield, S. Stanimirović, T.E. Holzer, U. Haud, V. Florinski, V. Florinski, W.R. Webber   +48 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Use of Mohr diagrams to predict fracturing in rock masses, with applications for predicting sub-surface behavior

iScience
Summary: Mohr diagrams are a simple and effective method that can help geoscientists consider, model, and predict the ranges of mechanical properties of rock, stresses, fluid pressures, and the resultant fractures that are likely to occur in the sub ...
D.C.P. Peacock, David J. Sanderson, Bernd Leiss   +2 more
doaj   +1 more source

Obituary − Emeritus Professor Dr John Davidson McCraw (1925−2014) MBE, MSc NZ, DSc Well, CRSNZ, FNZSSS. [PDF]

, 2015
John McCraw was an Earth scientist who began working as a pedologist with Soil Bureau, DSIR, then became the Foundation Professor of Earth Sciences at the University of Waikato in Hamilton, inspiring a new generation to study and work in Earth sciences .
Lowe, David J., Nelson, Campbell S., Tonkin, Philip J.   +2 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

From multi-hazard early warning systems (MHEWS) to all-vulnerability warning systems (AVWS)

iScience
Summary: Science, policy, and practice have long accepted that disasters occur due to vulnerabilities rather than hazards, yet approaches to warnings still tend to be hazard-focused.
Ilan Kelman, Carina J. Fearnley
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source