Results 101 to 110 of about 1,438,141 (312)

A surface-fitting program for areally- distributed data from the earth sciences and remote sensing [PDF]

Fortran II program for analysis of data from earth sciences and remote ...
Beckman, W. A., Jr., Krumbein, W. C., Waye, I., Whitten, E. H. T.   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Validating the application of cyclic hydraulic pressure pulses to reduce breakdown pressure in granite

iScience
Summary: As the geoenergy sector moves toward more sustainable practices, an emerging field of research is the proposed utilization of cyclic hydraulic pressure pulses to safely and efficiently enhance productivity.
Jackie Evan Kendrick, Anthony Lamur, Julien Mouli-Castillo, Alexander Lightbody, Andrew Fraser-Harris, Katriona Edlmann, Christopher Ian McDermott, Zoe Kai Shipton   +7 more
doaj   +1 more source

The 1984 NASA/ASEE summer faculty fellowship program [PDF]

An overview is given of the program management and activities. Participants and research advisors are listed. Abstracts give describe and present results of research assignments performed by 31 fellows either at the Johnson Space Center, at the White ...
Crow, B., Duke, M. B., Mcinnis, B. C.
core   +1 more source

Lidar remote sensing from space: NASA's plans in the Earth sciences [PDF]

, 1986
A multidisciplinary study of the Earth System to provide a better understanding of the complex interrelated processes involved in the system, the Earth Observing System (EOS), is being developed. Capabilities of the Space Station, both the polar orbiting
Curran, R. J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Earth Sciences Are the Model Sciences of the Anthropocene

Perspectives of Earth and Space Scientists
After 4.5 billion years as an evolving and dynamic planet, the Earth continues to evolve but with human‐altered dynamics. Earth scientists have special opportunities and responsibilities to accelerate our understanding of Earth's changes that are ...
Daniel D. Richter, Sharon A. Billings, Susan L. Brantley, Jerome Gaillardet, Daniel Markewitz, William H. Schlesinger, Ronald Amundson, Gail M. Ashley, Allan R. Bacon, Roger C. Bales, Dan Binkley, Zachary Brecheisen, Julio Calvo‐Alvarado, Nicolas Cassar, Chelsea Clifford, Louis A. Derry, Matt Edgeworth, Martha‐Cary Eppes, Ying Fan, Terry A. Ferguson, Marie‐Anne de Graaff, Jo Handelsman, Alfred E. Hartemink, Kirsten Hofmockel, Richard J. Huggett, Esteban G. Jobbagy, Hyun Seok Kim, Jagdish Krishnaswamy, Praveen Kumar, Susan Lozier, Louis Lu, William H. McDowell, John R. McNeill, Neung‐Hwan Oh, Katherine O’Neill, Mary E. Prendergast, Curtis J. Richardson, Justin B. Richardson, Paul A. Schroeder, Kate Scow, Christina Siebe, Aaron Thompson, Timothy White, Cathy L. Whitlock, Marilyn Wolf   +44 more
doaj   +1 more source

From multi-hazard early warning systems (MHEWS) to all-vulnerability warning systems (AVWS)

iScience
Summary: Science, policy, and practice have long accepted that disasters occur due to vulnerabilities rather than hazards, yet approaches to warnings still tend to be hazard-focused.
Ilan Kelman, Carina J. Fearnley
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Importance of Storing and Delivering Geochemical Data for Earth Science Collections [PDF]

, 2019
Giles Miller, Kerstin Lehnert
openalex   +1 more source