Results 101 to 110 of about 1,468,027 (343)
Earth Sciences Are the Model Sciences of the Anthropocene
Perspectives of Earth and Space ScientistsAfter 4.5 billion years as an evolving and dynamic planet, the Earth continues to evolve but with human‐altered dynamics. Earth scientists have special opportunities and responsibilities to accelerate our understanding of Earth's changes that are ...
Daniel D. Richter +44 more
doaj +1 more source
iScienceSummary: This perspective critically examines the challenges and opportunities of implementing people-centered multi-hazard early warning systems (MHEWS) in the Global South.
Budimir Mirianna +17 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Does democratic backsliding undermine climate policy? No evidence (yet)
iScienceSummary: Countries with liberal democratic institutions tend to have stricter climate policies and have made more progress in reducing emissions than autocracies.
Thomas Bernauer, Tobias Böhmelt
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
iScienceSummary: Environmental (in)justice research uses various conceptual frameworks and methodological approaches, leading to fragmentation across contexts and disciplines.
Jacqueline Loos +5 more
doaj +1 more source
The 1984 NASA/ASEE summer faculty fellowship program [PDF]
An overview is given of the program management and activities. Participants and research advisors are listed. Abstracts give describe and present results of research assignments performed by 31 fellows either at the Johnson Space Center, at the White ...
Crow, B., Duke, M. B., Mcinnis, B. C.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Amendment of saline-alkali soils promotes the formation and stability of iron-bound organic carbon
iScienceSummary: Iron oxides protect soil organic carbon (SOC) over the long term, but the effects of saline-alkali soil amendments on iron-bound organic carbon (Fe-OC) remain unclear.
Shuhan Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source