Results 101 to 110 of about 1,474,341 (311)

Measuring environmental (in)justices: Insights from a systematic literature review on methodological approaches

open access: yesiScience
Summary: Environmental (in)justice research uses various conceptual frameworks and methodological approaches, leading to fragmentation across contexts and disciplines.
Jacqueline Loos   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Earth Sciences Are the Model Sciences of the Anthropocene

open access: yesPerspectives of Earth and Space Scientists
After 4.5 billion years as an evolving and dynamic planet, the Earth continues to evolve but with human‐altered dynamics. Earth scientists have special opportunities and responsibilities to accelerate our understanding of Earth's changes that are ...
Daniel D. Richter   +44 more
doaj   +1 more source

Does democratic backsliding undermine climate policy? No evidence (yet)

open access: yesiScience
Summary: Countries with liberal democratic institutions tend to have stricter climate policies and have made more progress in reducing emissions than autocracies.
Thomas Bernauer, Tobias Böhmelt
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Amendment of saline-alkali soils promotes the formation and stability of iron-bound organic carbon

open access: yesiScience
Summary: Iron oxides protect soil organic carbon (SOC) over the long term, but the effects of saline-alkali soil amendments on iron-bound organic carbon (Fe-OC) remain unclear.
Shuhan Wang   +5 more
doaj   +1 more source

Lidar remote sensing from space: NASA's plans in the Earth sciences [PDF]

open access: yes, 1986
A multidisciplinary study of the Earth System to provide a better understanding of the complex interrelated processes involved in the system, the Earth Observing System (EOS), is being developed. Capabilities of the Space Station, both the polar orbiting
Curran, R. J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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