Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Por unas ciencias ambientales y unas ciencias de la tierra : reflexiones críticas y propuestas para un debate [PDF]
, 1998 Earth and Environmental Sciences are analysed in criticism form. A differentiation of Environmental Sciences and Earth Sciences as different subjects is proposed.
Pascual Trillo, J.A.
core +2 more sources
A Machine Learning-Based Approach to Clinopyroxene Thermobarometry: Model Optimization and Distribution for Use in Earth Sciences. [PDF]
J Geophys Res Solid Earth, 2022 Jorgenson C +4 more
europepmc +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Environmental Earth Sciences Progress Report 2020 and Outlook 2021. [PDF]
Environ Earth Sci, 2021 Kolditz O +14 more
europepmc +1 more source
A surface-fitting program for areally- distributed data from the earth sciences and remote sensing [PDF]
Fortran II program for analysis of data from earth sciences and remote ...
Beckman, W. A., Jr. +3 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Assessing river discharge dynamics through relative surface water extent changes in river basins
iScienceSummary: Surface water in rivers is vital for human society. However, our current understanding of the dynamics and drivers of river flows relies predominantly on stream gauging data, which are limited in spatial coverage and involve significant costs ...
Feng Mao +4 more
doaj +1 more source
Report on active and planned spacecraft and experiments [PDF]
Information is presented, concerning active and planned spacecraft and experiments known to the National Space Science Data Center. The information included a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy,
Horowitz, R. +2 more
core +1 more source