Results 71 to 80 of about 12,327,519 (291)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Thermodynamics and Equilibria in Earth System Sciences: An Introduction [PDF]

Thermodynamics is needed to understand many processes on Earth, be they physical, chemical, or biological. Thermodynamics is critical to study the atmosphere (lapse rate, fohn winds, circulation), hydrosphere (latent and sensible heat, pressure ...
Middelburg, Jack J.
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2018)

, 2018
University of Minnesota Duluth. Department of Earth and Environmental Sciences. (2018). UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2018).
University of Minnesota Duluth. Department of Earth and Environmental Sciences
core  

Approach for characterizing technology- and infrastructure-induced linkages between sustainable development goals

STAR Protocols
Summary: Technology and infrastructure investments targeting a primary sustainable development goal (SDG) can impact other SDGs. Understanding how linkages are shaped by technology characteristics is vital to design efforts that deliberately leverage co ...
Magdalena M. Klemun, Sanna Ojanperä, Amy Schweikert   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Protocol for extraction and analysis of microplastics in freshwater, sediment, and fish samples

STAR Protocols
Summary: Microplastic pollution threatens aquatic ecosystems and food webs. Here, we present a protocol for extracting microplastics from freshwater, sediment, and fish digestive system samples.
Tuncay Vural, Soner Çetinkaya, Vedat Yeğen, Selman Şapcıoğlu, Sedat Gündoğdu   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

NATURAL HAZARDS AND EARTH SYSTEM SCIENCES (ISSN: 1561-8633)

, 2010
Natural Hazards and Earth System Sciences (NHESS) is an interdisciplinary and international journal dedicated to the public discussion and open-access publication of high-quality studies and original research on natural hazards and their consequences ...
PINARDI, NADIA
core   +1 more source

Protocol for identifying compound heat-danger and ozone-pollution hotspots and their synoptic drivers

STAR Protocols
Summary: The co-occurrence of heat danger and ozone pollution amplifies risks to human health. Here, we present a protocol for quantifying heat danger using the Heat Index and identifying ozone pollution using maximum daily 8-h averages.
Jiayi Wang, Qian Liang, Yucong Miao
doaj   +1 more source