Results 61 to 70 of about 1,481,460 (305)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Protocol to calculate the climate effects of the global aviation industry using the Aviation-FAIR model

STAR Protocols
Summary: The rapid growth of the aviation industry has significantly impacted global climate change. We present a protocol to assess the climate effects of global aviation emissions.
Qiang Cui, Ying Zhou
doaj   +1 more source

Study of methanogenic enrichment cultures of rock cores from the deep subsurface of the Iberian Pyritic Belt

Heliyon, 2018
Two deep boreholes were drilled at 320 and 620 meters below surface in the Iberian Pyritic Belt (IPB) at Peña de Hierro (Huelva, Southwestern Spain). Cores were sampled and used for the establishment of enrichment cultures with methanogenic activity. The
Tânia Leandro, Nuria Rodriguez, Patricia Rojas, Jose L. Sanz, Milton S. da Costa, Ricardo Amils   +5 more
doaj   +1 more source

Introduction to the special section on Fundamental and Frontier Research in Rock Magnetism [PDF]

, 2006
Many of the papers in this special section were first presented in the session “Rock Magnetism: Fundamentals and Frontiers” at the 2005 Fall AGU meeting.
Alexei Smirnov, Carter-Stiglitz, Doubrovine, Dunlop, Dunlop, Dunlop, Dunlop, Dunlop, Dunlop, Egli, Egli, Evans, Feinberg, Fukuma, Halgedahl, Krasa, Merrill, Michael J. Jackson, Nagata, Ozima, Pan, Smirnov, Williams, Wyn Williams, Yu, Özdemir   +25 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Approach for characterizing technology- and infrastructure-induced linkages between sustainable development goals

STAR Protocols
Summary: Technology and infrastructure investments targeting a primary sustainable development goal (SDG) can impact other SDGs. Understanding how linkages are shaped by technology characteristics is vital to design efforts that deliberately leverage co ...
Magdalena M. Klemun, Sanna Ojanperä, Amy Schweikert   +2 more
doaj   +1 more source

Resolving spatiotemporal characteristics of the seasonal hypoxia cycle in shallow estuarine environments of the Severn River and South River, MD, Chesapeake Bay, USA

Heliyon, 2016
The nature of emerging patterns concerning water quality stressors and the evolution of hypoxia within sub-estuaries of the Chesapeake Bay has been an important unresolved question among the Chesapeake Bay community.
Andrew C. Muller, Diana L. Muller, Arianna Muller   +2 more
doaj   +1 more source

Opportunities for Characterizing Geological Flows Using Magnetic Resonance Imaging

iScience, 2020
Summary: Geological flows—from mudslides to volcanic eruptions—are often opaque and consist of multiple interacting phases. Scaled laboratory geological experiments using analog materials have often been limited to optical imaging of flow exteriors or ex
Einat Lev, Christopher M. Boyce
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source