Results 131 to 140 of about 1,468,027 (343)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Electrokinetics in Earth Sciences
International Journal of Geophysics, 2013 Laurence Jouniaux, Tsuneo Ishido
doaj +1 more source
An indexing and classification system for earth-science data bases [PDF]
, 1989 James C. Schornick +3 more
openalex +1 more source
Conceptual design study of the science payload for the Earth 2.0 mission
, 2022 Yonghe Chen +19 more
openalex +2 more sources
Optical Mineralogy in a Modern Earth Sciences Curriculum [PDF]
, 2007 Provides pedagogical insight concerning the skill of studying minerals The resource being annotated is: http://www.dlese.org/dds/catalog_SERC-NAGT-000-000-000-651 ...
Lamont-Doherty Earth Observatory, Columbia University
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Lyell Collection at the Earth Sciences Department, Natural History Museum, London (UK). [PDF]
Biodivers Data J, 2019 Sendino C.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source