Results 61 to 70 of about 253,500 (286)

Approach for characterizing technology- and infrastructure-induced linkages between sustainable development goals

STAR Protocols
Summary: Technology and infrastructure investments targeting a primary sustainable development goal (SDG) can impact other SDGs. Understanding how linkages are shaped by technology characteristics is vital to design efforts that deliberately leverage co ...
Magdalena M. Klemun, Sanna Ojanperä, Amy Schweikert   +2 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Protocol for extraction and analysis of microplastics in freshwater, sediment, and fish samples

STAR Protocols
Summary: Microplastic pollution threatens aquatic ecosystems and food webs. Here, we present a protocol for extracting microplastics from freshwater, sediment, and fish digestive system samples.
Tuncay Vural, Soner Çetinkaya, Vedat Yeğen, Selman Şapcıoğlu, Sedat Gündoğdu   +4 more
doaj   +1 more source

A Heritage Science Workflow to Preserve and Narrate a Rural Archeological Landscape Using Virtual Reality: The Cerro del Castillo of Belmez and Its Surrounding Environment (Cordoba, Spain)

Applied Sciences, 2020
The main aim of this article is to present a heritage action protocol based on the application of photogrammetric and LiDAR acquisitions, a catalogue of flora and fauna, archeological research, and 3D virtualization for the integrated recovery of a rural
Antonio Monterroso-Checa, Alberto Redondo-Villa, Massimo Gasparini, Alberto Hornero, Bernardo Iraci, Rafael Martín-Talaverano, Juan Carlos Moreno-Escribano, Jesús Muñoz-Cádiz, José Ignacio Murillo-Fragero, Rafael Obregón-Romero, Noël Vargas, Simon J. Young, Raul Yuste, Pablo J. Zarco-Tejada   +13 more
doaj   +1 more source

Geomorphology and Earth system science [PDF]

Progress in Physical Geography: Earth and Environment, 2010
Earth system science (ESS) is an approach to: ‘obtain a scientific understanding of the entire Earth system on a global scale by describing how its component parts and their interactions have evolved, how they function, and how they may be expected to continue to evolve on all timescales’ (Bretherton, 1998). The aim of this review is to introduce some
openaire   +4 more sources

Mining sciences in the branch of Earth sciences

Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal, 2021
Problem statement. What is mining science? Is it craft, art of “treasure hunters”, or science? What underlies the theory of mineral extraction? What is its place within the system of knowledge of the environment? Discussion. Today there is no precise, clear, and conventional definition of mining science, its matter and object.
Galianov Aleksei, Iakovlev Viktor
openaire   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Assessing river discharge dynamics through relative surface water extent changes in river basins

iScience
Summary: Surface water in rivers is vital for human society. However, our current understanding of the dynamics and drivers of river flows relies predominantly on stream gauging data, which are limited in spatial coverage and involve significant costs ...
Feng Mao, Margaret Shanafield, Val Ouellet, David M. Hannah, Stefan Krause   +4 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source