Results 81 to 90 of about 1,466,569 (295)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The fate of William Whewell’s four palætiological domains : a comparative study [PDF]
, 2019 In 1847, the British polymath William Whewell pointed out that the sciences for which he, in 1837, had coined the term “palætiological” have much in common and that they may reflect light upon each other by being treated together.
Tanghe, Koen
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
The 1984 NASA/ASEE summer faculty fellowship program [PDF]
An overview is given of the program management and activities. Participants and research advisors are listed. Abstracts give describe and present results of research assignments performed by 31 fellows either at the Johnson Space Center, at the White ...
Crow, B., Duke, M. B., Mcinnis, B. C.
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, 1970 Offices Move To Chapman -- HUNDRED FACULTY ARRIVE -- Beistline Named First College Provost -- Hullinger Takes Comptroller Post -- New University Relations Director Is Writer and Administrator -- Campus Services Add Several Staffers -- COLLEGE OF ARTS AND
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
STS-9: Orbital Workshop Spacelab to Fly on Ninth Shuttle Mission [PDF]
The first non-astronants are discussed. Spacelab is described. Spacelab objectives, Spacelab 1 investigations, atmospheric physics and Earth observations, space plasma physics, solar physics and astronomy, material sciences and technology development ...
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Crowdfunding Astronomy Research with Google Sky [PDF]
, 2015 For nearly four years, NASA's Kepler space telescope searched for planets like Earth around more than 150,000 stars similar to the Sun. In 2008 with in-kind support from several technology companies, our non-profit organization established the Pale Blue ...
Metcalfe, Travis S.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source