Results 111 to 120 of about 249,122 (281)

Shaping Interconnected Geography in Central and Eastern European Academia—Key Research Challenges for the Future

Geo: Geography and Environment
Central and Eastern European geography, shaped by its entanglement of natural and social sciences, provides a distinctive lens for rethinking the unity of the discipline.
Mariusz Lamentowicz, Grzegorz Micek, Mateusz C. Strzelecki, Tomasz Wites   +3 more
doaj   +1 more source

In memoriam Attila Barczi (1964–2020)

Hungarian Geographical Bulletin, 2020
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Dénes Lóczy
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Quantifying slope-channel coupling in an active gully and fan complex at Tarndale, Waipaoa catchment, New Zealand [PDF]

, 2010
Two RIEGL LMS‐Z420i scanner surveys (November 2007 and November 2008) of the Tarndale Gully complex and its associated fan were used to generate a digital elevation model (DEM) of difference in order to quantify gully‐fan‐channel connectivity.
Dean, Josh F, Fuller, Ian C, Marden, Mike, Massey, Chris, Phillips, Emma   +4 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Estimation of flow rate calculation errors on the example of five rapid response catchments in the Mecsek Hills

Hungarian Geographical Bulletin, 2013
Today flash floods are one of the most significant extreme weather-related natural hazards. Due to the global climate change and altered land use, intense runoff and flash floods may exert catastrophic hydrologic impacts on developed areas.
Péter Hegedűs, Szabolcs Czigány, Ervin Pirkhoffer, László Balatonyi, Levente Ronczyk   +4 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Open Access Journals / Institutional Repositories [PDF]

, 2008
Düpow, Heidi, Finke, Angelika, Schmidt, Barbara   +2 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source