Results 111 to 120 of about 1,585,067 (292)

Editorial: Extreme precipitation in arid regions: observation, mechanisms, and simulations

Frontiers in Earth Science, 2023
Chenghai Wang, Kai Yang, Zhigang Wei, Bo Huang   +3 more
doaj   +1 more source

The Impact of Horizontal Resolution on Projected Sea-Level Rise Along US East Continental Shelf With the Community Earth System Model. [PDF]

J Adv Model Earth Syst, 2022
Li D, Chang P, Yeager SG, Danabasoglu G, Castruccio FS, Small J, Wang H, Zhang Q, Gopal A.   +8 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interannual and Seasonal Drivers of Carbon Cycle Variability Represented by the Community Earth System Model (CESM2). [PDF]

Global Biogeochem Cycles, 2021
Wieder WR, Butterfield Z, Lindsay K, Lombardozzi DL, Keppel-Aleks G.   +4 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Replicability in Earth System Models

Abstract. Climate simulations with Earth System Models (ESMs) constitute the basis of our knowledge about the projected climate change for the coming decades. They represent the major source of knowledge for the Intergovernmental Panel on Climate Change (IPCC), and are an indispensable tool in confronting climate change. Yet, ESMs are imperfect and the
Kai Rasmus Keller, Marta Alerany Solé, Mario Acosta   +2 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Increasing the spatial and temporal impact of ecological research: A roadmap for integrating a novel terrestrial process into an Earth system model. [PDF]

Glob Chang Biol, 2022
Kyker-Snowman E, Lombardozzi DL, Bonan GB, Cheng SJ, Dukes JS, Frey SD, Jacobs EM, McNellis R, Rady JM, Smith NG, Thomas RQ, Wieder WR, Grandy AS.   +12 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Description and Demonstration of the Coupled Community Earth System Model v2 - Community Ice Sheet Model v2 (CESM2-CISM2). [PDF]

J Adv Model Earth Syst, 2021
Muntjewerf L, Sacks WJ, Lofverstrom M, Fyke J, Lipscomb WH, Ernani da Silva C, Vizcaino M, Thayer-Calder K, Lenaerts JTM, Sellevold R.   +9 more
europepmc   +1 more source