Results 131 to 140 of about 1,585,067 (292)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Arctic Clouds and Precipitation in the Community Earth System Model Version 2. [PDF]

J Geophys Res Atmos, 2020
McIlhattan EA, Kay JE, L'Ecuyer TS.
europepmc   +1 more source

Evaluating Global Warming Potentials as Historical Temperature Proxies: an application of ACC2 Inverse Calculation [PDF]

Global Warming Potentials (GWPs) are evaluated as proxies of the historical temperature by applying them to convert historical CH4 and N2O emissions to equivalent CO2 emissions.
Brian C. O'Neill, Dmitry Rokityanskiy, Katsumasa Tanaka, Michael Obersteiner, Richard S.J. Tol   +4 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A trajectory generation and system characterization model for cislunar low-thrust spacecraft. Volume 2: Technical manual [PDF]

The documentation of the Trajectory Generation and System Characterization Model for the Cislunar Low-Thrust Spacecraft is presented in Technical and User's Manuals.
Bilby, Curt R., Korsmeyer, David J., Oconnor, Brendan M., Pinon, Elfego, III   +3 more
core   +1 more source

The IITM earth system model

, 2015
With the goal of building an Earth system model appropriate for detection, attribution, and projection of changes in the South Asian monsoon, a state-of-the-art seasonal prediction model, namely the Climate Forecast System version 2 (CFSv2) has been adapted to a climate model suitable for extended climate simulations at the Indian Institute of Tropical
Swapna, P., Roxy, M., Aparna, K., Kulkarni, K., Prajeesh, A., Ashok, K., Krishnan, R., Moorthi, S., Kumar, A., Goswami, B.   +9 more
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A Greening Future Elevates Flash Drought Risk in Northern Mid‐to‐High Latitudes

Earth's Future
Flash droughts have become a growing concern, as they can emerge rapidly and increase the risk of crop failure. Although past studies have investigated the meteorological drivers and future changes of flash drought, why flash drought is more frequent ...
Zeyu Xue, L. Ruby Leung, Paul A. Ullrich
doaj   +1 more source