Results 71 to 80 of about 1,585,067 (292)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
, 2001 Earth system analysis — this term is often associated with the study of the ‘solid’ Earth with its surrounding spheres, the atmosphere, cryosphere, and hydrosphere. However, within IGBP (the International Geosphere — Biosphere Programme) — at least — a more general definition, which has been proposed by Schellnhuber (1998, 1999) and Claussen (1998 ...
openaire +3 more sources
Tipping points in complex coupled life-environment systems
, 2013 Simple models of complex phenomena provide powerful insights and suggest low-level mechanistic descriptions. The Earth system arises from the interaction of subsystems with multi-scale temporal and spatial variability; from the microbial to continental ...
Dyke, James G., Weaver, Iain S.
core +1 more source
A Community Approach to Earth Systems Modeling [PDF]
Eos, Transactions American Geophysical Union, 2010 Earth science often deals with complex systems spanning multiple disciplines. These systems are best described by integrated models built with contributions from specialists of many backgrounds. But building integrated models can be difficult; modular and hierarchical approaches help to manage the increasing complexity of these modeling systems, but ...
Voinov, A. +5 more
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Formation of the Terrestrial Planets from a Narrow Annulus
, 2009 We show that the assembly of the Solar System terrestrial planets can be successfully modelled with all of the mass initially confined to a narrow annulus between 0.7 and 1.0 AU.
Brad M. S. Hansen +20 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
An agenda for the future of Arctic snow research: the view from Svalbard
Polar ResearchThe Arctic region is warming at over twice the mean rate of the Northern Hemisphere and nearly four times faster than the globe since 1979. The local rate of warming is even higher in the European archipelago of Svalbard. This warming is transforming the
Christian Zdanowicz +7 more
doaj +1 more source
Environmental Research Letters, 2017 Subsurface temperature profiles measured in boreholes are one of the important archives of paleoclimate data for reconstructing the climate of the past 2000 years.
Andrew H MacDougall, Hugo Beltrami
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source