Results 81 to 90 of about 1,585,067 (292)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Large-Eddy Simulation of Dry and Moist Atmospheric Boundary Layers and Analysis of the Model Convergence

Gaoyuan qixiang
By using the large eddy simulation （LES） version of the Weather Research and Forecasting （WRF） model， vertical structure and the feature of turbulent transportation of shallow-convective-cloud-topped atmospheric convective boundary layer was simulated in
Yixin ZHANG, Xindong PENG
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Atmospheric circulation of tidally locked exoplanets: a suite of benchmark tests for dynamical solvers

, 2011
The complexity of atmospheric modelling and its inherent non-linearity, together with the limited amount of data of exoplanets available, motivate model intercomparisons and benchmark tests.
Adcroft, Anderson, Asselin, Burrows, Cho, Cho, Cooper, Cooper, Dobbs-Dixon, Goodman, Gordon, Held, Held, Heng, Holton, Iro, Kevin Heng, Kristen Menou, Kundu, Langton, Li, Longuet-Higgins, Menou, Menou, Merlis, Peter J. Phillipps, Phillips, Rauscher, Roeckner, Seager, Shapiro, Shapiro, Showman, Showman, Showman, Showman, Simmons, Smagorinsky, Smagorinsky, Snellen, Stephenson, Takacs, Thrastarson, Udry, Vallis, Washington, Wyman   +46 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Australian Earth System Model: ACCESS-ESM1.5 [PDF]

Journal of Southern Hemisphere Earth Systems Science, 2020
The Australian Community Climate and Earth System Simulator (ACCESS) has been extended to include land and ocean carbon cycle components to form an Earth System Model (ESM).
Jhan Srbinovsky, Ying-Ping Wang, Lauren Stevens, Martin Dix, Roger W. Bodman, Andrew Lenton, Rachel M. Law, Matthew A. Chamberlain, Tilo Ziehn   +8 more
doaj  

Program management model study [PDF]

Two models, a system performance model and a program assessment model, have been developed to assist NASA management in the evaluation of development alternatives for the Earth Observations Program.
Connelly, J. J., Russell, J. E., Seline, J. R., Sumner, N. R., Jr.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Periodicity of mass extinctions without an extraterrestrial cause

, 2005
We study a lattice model of a multi-species prey-predator system. Numerical results show that for a small mutation rate the model develops irregular long-period oscillatory behavior with sizeable changes in a number of species.
B. Drossel, C. Quince, J. D. Murray, J. Hofbauer, M. E. J. Newman, S. M. Stanley   +5 more
core   +1 more source