Results 141 to 150 of about 1,185,812 (300)

The IITM earth system model

, 2015
With the goal of building an Earth system model appropriate for detection, attribution, and projection of changes in the South Asian monsoon, a state-of-the-art seasonal prediction model, namely the Climate Forecast System version 2 (CFSv2) has been adapted to a climate model suitable for extended climate simulations at the Indian Institute of Tropical
Swapna, P., Roxy, M., Aparna, K., Kulkarni, K., Prajeesh, A., Ashok, K., Krishnan, R., Moorthi, S., Kumar, A., Goswami, B.   +9 more
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Recommendations for Comprehensive and Independent Evaluation of Machine Learning‐Based Earth System Models

Journal of Geophysical Research: Machine Learning and Computation
Machine learning (ML) is a revolutionary technology with demonstrable applications across multiple disciplines. Within the Earth science community, ML has been most visible for weather forecasting, producing forecasts that rival modern physics‐based ...
P. A. Ullrich, E. A. Barnes, W. D. Collins, K. Dagon, S. Duan, J. Elms, J. Lee, L. R. Leung, D. Lu, M. J. Molina, T. A. O’Brien, F. O. Rebassoo   +11 more
doaj   +1 more source

Towards Earth system modelling: coupled ocean forecasting

Ocean prediction: present status and state of the art (OPSR)
Abstract. Modelling our planet is challenging, and forecasting the ocean component is crucial for better understating physical processes in a changing climate. To achieve this objective, numerical ocean models require more advanced approaches that aim at connecting different Earth system’s components in a more sophisticated way: this is offered by ...
Ségolène Berthou, John Siddorn, Vivian Fraser-Leonhardt, Pierre-Yves Le Traon, Ibrahim Hoteit   +4 more
openaire   +3 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Preservation of Data for Earth System Science- Towards a Content Standard [PDF]

Various remote sensing agencies of the world have created a data rich environment for research and applications over the last three decades. Especially over the last decade, the volume and variety of data useful for Earth system science have increased ...
Duerr, Ruth, Moses, John, Ramapriyan, Hampapuram   +2 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Origin of life [PDF]

The pathways of organic chemical synthesis, the chemical evolution on the early Earth leading to life was constrained by the development of the planet by accretion and core formation.
Chang, S.
core   +1 more source