Results 121 to 130 of about 1,185,812 (300)

Confronting Earth System Model trends with observations

Science Advances
Anthropogenically forced climate change signals are emerging from the noise of internal variability in observations, and the impacts on society are growing. For decades, Climate or Earth System Models have been predicting how these climate change signals will unfold.
Isla R. Simpson, Tiffany A. Shaw, Paulo Ceppi, Amy C. Clement, Erich Fischer, Kevin M. Grise, Angeline G. Pendergrass, James A. Screen, Robert C. J. Wills, Tim Woollings, Russell Blackport, Joonsuk M. Kang, Stephen Po-Chedley   +12 more
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Showcasing MESMER-X: Spatially Resolved Emulation of Annual Maximum Temperatures of Earth System Models. [PDF]

Geophys Res Lett, 2022
Quilcaille Y, Gudmundsson L, Beusch L, Hauser M, Seneviratne SI.   +4 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

A Two‐Column Model Parameterization for Subgrid Surface Heterogeneity Driven Circulations

Journal of Advances in Modeling Earth Systems
Earth system models currently struggle to account for the complex effects that land surface heterogeneity can have on land‐atmosphere interactions. There have been attempts to include the impact of this heterogeneity on the atmosphere, but they ignore ...
T. Waterman, A. D. Bragg, F. Hay‐Chapman, P. A. Dirmeyer, M. D. Fowler, J. Simon, N. Chaney   +6 more
doaj   +1 more source

Correction to 'Learning earth system models from observations: machine learning or data assimilation?' [PDF]

Philos Trans A Math Phys Eng Sci, 2022
Geer AJ.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Current and Future Climate Extremes Over Latin America and Caribbean: Assessing Earth System Models from High Resolution Model Intercomparison Project (HighResMIP). [PDF]

Earth Syst Environ, 2023
Avila-Diaz A, Torres RR, Zuluaga CF, Cerón WL, Oliveira L, Benezoli V, Rivera IA, Marengo JA, Wilson AB, Medeiros F.   +9 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multi‐Model Simulation of Solar Geoengineering Indicates Avoidable Destabilization of the West Antarctic Ice Sheet

Earth's Future
Heat transported in Circumpolar Deep Water is driving the break‐up of ice shelves in the Amundsen Sea sector of Antarctica, that has been simulated to be unavoidable under all plausible greenhouse gas scenarios.
John C. Moore, Chao Yue, Yangxin Chen, Svetlana Jevrejeva, Daniele Visioni, Petteri Uotila, Liyun Zhao   +6 more
doaj   +1 more source