Results 111 to 120 of about 1,185,812 (300)

Northern Eurasia Future Initiative (NEFI): facing the challenges and pathways of global change in the twenty-first century [PDF]

, 2017
During the past several decades, the Earth system has changed significantly, especially across Northern Eurasia. Changes in the socio-economic conditions of the larger countries in the region have also resulted in a variety of regional environmental ...
Albrechtova, Jana, Bergen, Kathleen, Chen, Jiquan, Groisman, Pavel Ya., Gulev, Sergey, Gutman, Garik, Henebry, Geoffrey, Kicklighter, David, Kukavskaya, Elena, Loboda, Tatiana, Maksyutov, Shamil, Monier, Erwan, Nghiem, Son, Porfiriev, Boris, Prishchepov, Alexander, Qi, Jiaguo, Shahgedanova, Maria, Shiklomanov, Alexander I., Shiklomanov, Nikolay, Shugart, Herman, Shvidenko, Anatoly, Soja, Amber, Speranskaya, Nina, Tchebakova, Nadezhda   +23 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Reimagining Earth in the Earth System

Journal of Advances in Modeling Earth Systems
Terrestrial, aquatic, and marine ecosystems regulate climate at local to global scales through exchanges of energy and matter with the atmosphere and assist with climate change mitigation through nature‐based climate solutions.
Gordon B. Bonan, Oliver Lucier, Deborah R. Coen, Adrianna C. Foster, Jacquelyn K. Shuman, Marysa M. Laguë, Abigail L. S. Swann, Danica L. Lombardozzi, William R. Wieder, Kyla M. Dahlin, Adrian V. Rocha, Michael D. SanClements   +11 more
doaj   +1 more source

A trajectory generation and system characterization model for cislunar low-thrust spacecraft. Volume 2: Technical manual [PDF]

The documentation of the Trajectory Generation and System Characterization Model for the Cislunar Low-Thrust Spacecraft is presented in Technical and User's Manuals.
Bilby, Curt R., Korsmeyer, David J., Oconnor, Brendan M., Pinon, Elfego, III   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

PT-ESM: A Parameter-Testing and Integration Framework for Earth System Models Oriented towards High-Performance Computing

Atmosphere
High-performance computing (HPC) plays a crucial role in scientific computing, and the efficient utilization of HPC to accomplish computational tasks remains a focal point of research.
Jiaxu Guo, Liang Hu, Gaochao Xu, Juncheng Hu, Xilong Che   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Overestimated nitrogen loss from denitrification for natural terrestrial ecosystems in CMIP6 Earth System Models. [PDF]

Nat Commun, 2023
Feng M, Peng S, Wang Y, Ciais P, Goll DS, Chang J, Fang Y, Houlton BZ, Liu G, Sun Y, Xi Y.   +10 more
europepmc   +1 more source

The effect of surface reflection and clouds on the estimation of total ozone from satellite measurements [PDF]

The total amount of ozone in a vertical column is being measured by Nimbus 4 and 7 observations of the intensity of ultraviolet sunlight scattered from the earth.
Ahmad, Z., Fraser, R. S.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source