Results 101 to 110 of about 1,185,812 (300)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Editorial for the Special Issue “Assimilation of Remote Sensing Data into Earth System Models”
Remote Sensing, 2019 This Special Issue is a collection of papers reporting research on various aspects of coupled data assimilation in Earth system models. It includes contributions presenting recent progress in ocean−atmosphere, land−atmosphere, and soil− ...
Jean-Christophe Calvet +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The orbit of 2010 TK7. Possible regions of stability for other Earth Trojan asteroids
, 2012 Recently the first Earth Trojan has been observed (Mainzer et al., ApJ 731) and found to be on an interesting orbit close to the Lagrange point L4 (Connors et al., Nature 475).
Bien +46 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Climate models miss most of the coarse dust in the atmosphere. [PDF]
, 2020 Coarse mineral dust (diameter, ≥5 μm) is an important component of the Earth system that affects clouds, ocean ecosystems, and climate. Despite their significance, climate models consistently underestimate the amount of coarse dust in the atmosphere when
Adebiyi, Adeyemi A, Kok, Jasper F
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Ecology and SocietyIn this article we analyze participatory approaches used in three research studies where local ecological knowledge (LEK) and Earth system models (ESMs) were combined to deepen our understanding of human-environment systems and produce usable data tools ...
Kelsey A Emard +10 more
doaj +1 more source
Evaluation of advanced geopotential models for operational orbit determination [PDF]
To meet future orbit determination accuracy requirements for different NASA projects, analyses are performed using Tracking and Data Relay Satellite System (TDRSS) tracking measurements and orbit determination improvements in areas such as the modeling ...
Davis, B. E. +4 more
core +1 more source