Results 81 to 90 of about 1,185,812 (300)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Observed allocations of productivity and biomass, and turnover times in tropical forests are not accurately represented in CMIP5 Earth system models

Environmental Research Letters, 2015
A significant fraction of anthropogenic CO _2 emissions is assimilated by tropical forests and stored as biomass, slowing the accumulation of CO _2 in the atmosphere.
Robinson I Negrón-Juárez, Charles D Koven, William J Riley, Ryan G Knox, Jeffrey Q Chambers   +4 more
doaj   +1 more source

Formation of the Terrestrial Planets from a Narrow Annulus

, 2009
We show that the assembly of the Solar System terrestrial planets can be successfully modelled with all of the mass initially confined to a narrow annulus between 0.7 and 1.0 AU.
Brad M. S. Hansen, Cameron, Chambers, Currie, Haghighipour, Hansen, Jacobsen, Jin, Johnson, Konacki, Kretke, Masset, Morishima, Rice, Safronov, Thommes, Weidenschilling, Wetherill, Youdin, Youdin, Youdin   +20 more
core   +1 more source

The Space Environment and Atmospheric Joule Heating of the Habitable Zone Exoplanet TOI700-d

, 2020
We investigate the space environment conditions near the Earth-size planet TOI~700~d using a set of numerical models for the stellar corona and wind, the planetary magnetosphere, and the planetary ionosphere.
Alvarado-Gomez, J., Cohen, O., Drake, J., Fraschetti, F., Garraffo, C., Glocer, A., Moschou, S.   +6 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Heuristic Strategy to Compute Ensemble of Trajectories for 3D Low Cost Earth-Moon Transfers [PDF]

, 2016
The problem of finding optimal trajectories is essential for modern space mission design. When considering multibody gravitational dynamics and exploiting both low-thrust and high-thrust and alternative forms of propulsion such as solar sailing, sets ...
Ceriotti, Matteo, de Sousa-Silva, Priscilla A., McInnes, Colin R., Terra, Maisa O.   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Earth and Terrestrial Planet Formation

, 2015
The growth and composition of Earth is a direct consequence of planet formation throughout the Solar System. We discuss the known history of the Solar System, the proposed stages of growth and how the early stages of planet formation may be dominated by ...
Agnor, Alexander, Allègre, Becker, Bitsch, Blum, Bottke, Bottke, Brasser, Briceño, Bryden, Carballido, Castillo-Rogez, Castillo-Rogez, Chambers, Chambers, Chambers, Chambers, Chambers, Chambers, Chapman, Cohen, Crida, Crida, Cuzzi, Cuzzi, D'Angelo, Dauphas, DeMeo, DeMeo, Dubrulle, Elkins-Tanton, Fernandez, Fischer, Goldreich, Gomes, Gomes, Greenberg, Haisch, Halliday, Hansen, Ida, Ida, Ida, Ikoma, Iwasaki, Izidoro, Jacobsen, Jacobson, Jacobson, Jin, Johansen, Johansen, Kita, Kley, Kley, Kobayashi, Kobayashi, Kokubo, Kokubo, Kokubo, Lambrechts, Lambrechts, Lambrechts, Laskar, Levison, Levison, Levison, Levison, Levison, Levison, Lin, Lissauer, Lécuyer, Malhotra, Mamajek, Marchi, Marchi, Marty, Masset, Morbidelli, Morbidelli, Morbidelli, Morbidelli, Morbidelli, Morbidelli, Morbidelli, Morbidelli, Morbidelli, Morishima, Muralidharan, Murray-Clay, Nagasawa, Nakagawa, Nesvorný, Nesvorný, Nimmo, O'Brien, O'Brien, Okuzumi, Ormel, Owen, Papaloizou, Papaloizou, Pfalzner, Pierens, Pierens, Pollack, Raymond, Raymond, Ryder, Ryder, Safronov, Snellgrove, Strom, Taylor, Tera, Thommes, Touboul, Tsiganis, Villeneuve, Wada, Wada, Wada, Walker, Walsh, Walsh, Walsh, Walsh, Ward, Weidenschilling, Weidenschilling, Weidenschilling, Weiss, Wetherill, Wetherill, Wetherill, Wetherill, Whipple, Yin, Youdin, Youdin, Zhou, Zsom, Ćuk, Ćuk   +145 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source