Results 71 to 80 of about 1,185,812 (300)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Deep Learning for Bias‐Correcting CMIP6‐Class Earth System Models

Earth's Future, 2023
The accurate representation of precipitation in Earth system models (ESMs) is crucial for reliable projections of the ecological and socioeconomic impacts in response to anthropogenic global warming. The complex cross‐scale interactions of processes that
Philipp Hess, Stefan Lange, Christof Schötz, Niklas Boers   +3 more
doaj   +1 more source

The habitability of super-Earths in Gliese 581

, 2007
Aims: The planetary system around the M star Gliese 581 consists of a hot Neptune (Gl 581b) and two super-Earths (Gl 581c and Gl 581d). The habitability of this system with respect to the super-Earths is investigated following a concept that studies the ...
Bean, Bonfils, Butler, C. Bounama, Chamberlain, Cuntz, Forget, Franck, Franck, Franck, Franck, Franck, Grenfell, Grießmeier, Jones, Joshi, Joshi, Kasting, Khodachenko, Lenton, M. Cuntz, Mischna, Ribas, S. Franck, Sleep, Stevenson, Tarter, Udry, Valencia, Valencia, Volk, Von Bloh, Von Bloh, Von Bloh, W. von Bloh, Walker, Williams   +36 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Program management model study [PDF]

Two models, a system performance model and a program assessment model, have been developed to assist NASA management in the evaluation of development alternatives for the Earth Observations Program.
Connelly, J. J., Russell, J. E., Seline, J. R., Sumner, N. R., Jr.   +3 more
core   +1 more source

The First Neptune Analog or Super-Earth with Neptune-like Orbit: MOA-2013-BLG-605Lb

, 2016
We present the discovery of the first Neptune analog exoplanet or super-Earth with Neptune-like orbit, MOA-2013-BLG-605Lb. This planet has a mass similar to that of Neptune or a super-Earth and it orbits at $9\sim 14$ times the expected position of the ...
A. Bhattacharya, A. Fukui, A. Gould, A. Sharan, A. Udalski, A. Yonehara, C-U. Lee, C. H. Ling, C. Han, D. J. Sullivan, D. P. Bennett, D. Suzuki, F. Abe, G. Pietrzyński, H. Oyokawa, I. A. Bond, I. Soszyński, I.-G Shin, J. B. Marquette, J. P. Beaulieu, J. Skowron, K. Masuda, K. Ohnishi, K. Ulaczyk, M. C. A. Li, M. Donachie, M. Freeman, M. K. Szymański, M. Kubiak, M. Nagakane, N. Koshimoto, N. Rattenbury, null null, null null, P. J. Tristram, P. Pietrukowicz, R. Poleski, R. W. Pogge, S. Brillant, S. Kozłowski, T. Bensby, T. Sumi, To. Saito, V. Batista, Y. Asakura, Y. Hirao, Y. Itow, Y. Matsubara, Y. Muraki, Y.-K. Jung, Ł. Wyrzykowski   +50 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A review of and perspectives on global change modeling for Northern Eurasia

Environmental Research Letters, 2017
Northern Eurasia is made up of a complex and diverse set of physical, ecological, climatic and human systems, which provide important ecosystem services including the storage of substantial stocks of carbon in its terrestrial ecosystems. At the same time,
Erwan Monier, David W Kicklighter, Andrei P Sokolov, Qianlai Zhuang, Irina N Sokolik, Richard Lawford, Martin Kappas, Sergey V Paltsev, Pavel Ya Groisman   +8 more
doaj   +1 more source

Earth System Modeling 2.0: A Blueprint for Models That Learn From Observations and Targeted High-Resolution Simulations [PDF]

, 2017
Climate projections continue to be marred by large uncertainties, which originate in processes that need to be parameterized, such as clouds, convection, and ecosystems. But rapid progress is now within reach.
Lan, Shiwei, Schneider, Tapio, Stuart, Andrew, Teixeira, João   +3 more
core   +2 more sources