Results 11 to 20 of about 13,340 (160)

TpUB05, a Homologue of the Immunodominant Plasmodium falciparum Protein UB05, Is a Marker of Protective Immune Responses in Cattle Experimentally Vaccinated against East Coast Fever. [PDF]

PLoS ONE, 2015
IntroductionEast Coast fever, a devastating disease of cattle, can be controlled partially by vaccination with live T. parva sporozoites. The antigens responsible for conferring immunity are not fully characterized.
Jerome Nyhalah Dinga, Mark Wamalwa, Dieudonné Lemuh Njimoh, Moses N Njahira, Appolinaire Djikeng, Rob Skilton, Vincent Pryde Kehdingha Titanji, Roger Pellé   +7 more
doaj   +2 more sources

An Improved Theileria parva Sporozoite Seroneutralization Assay for the Identification of East Coast Fever Immune Correlates [PDF]

Antibodies
Background: Immune correlates of protection are ideal tools to predict treatment or vaccine efficacy. However, the accuracy of the immune correlate and the capability to robustly predict the outcome of a vaccine candidate are determined by the ...
Hannah Chege, Samuel Githigia, James Gathumbi, Naomi Chege, Rose Ojuok, Josiah Odaba, Stephen Mwalimu, Harriet Oboge, Lucilla Steinaa, Vishvanath Nene, Anna Lacasta   +10 more
doaj   +2 more sources

Unveiling the tick-borne pathogens from domestic ruminant ticks in Malawi and the emergence of the brown ear tick in the southern region: implications for East Coast fever control [PDF]

Parasite
Ticks transmit a wide range of protozoan, bacterial, and viral pathogens to humans and animals globally. However, data on ticks infesting domestic ruminants and the pathogens they carry are scarce in Malawi.
Chikufenji Boniface, Mohanta Uday Kumar, Chatanga Elisha, Stopher Dallion, Ceylan Onur, Umemiya-Shirafuji Rika, Thekisoe Oriel, Nkhata Madalitso, Sugi Tatsuki, Yamagishi Junya, Xuan Xuenan, Hayashida Kyoko   +11 more
doaj   +2 more sources

Epidemiology of East Coast fever (Theileria parva infection) in Kenya: past, present and the future [PDF]

Parasites & Vectors, 2012
In this article, we review the epidemiology of East Coast fever (ECF), a tick-borne infection of cattle, in Kenya. The major factors associated with epidemiology of ECF include the agro-ecological zone (AEZ), livestock production system (LPS) and both ...
Gachohi John, Skilton Rob, Hansen Frank, Ngumi Priscilla, Kitala Philip   +4 more
doaj   +2 more sources

The control of East Coast fever of cattle by live parasite vaccination: A science-to-impact narrative [PDF]

One Health, 2016
There is an increasing interest in determining the impact of vaccine technologies developed using public funding targeted at international development, and understanding the factors and ingredients which contribute to the success and impacts of such ...
B.D. Perry
doaj   +2 more sources

Dogmas and misunderstandings in East Coast fever [PDF]

Tropical Medicine and International Health, 1999
Summary East Coast fever (ECF) is the most important tick‐borne disease in eastern, central and southern Africa and caused an estimated loss of US $186 million in 1989 in the 11 countries where it occurs. It was brought to southern Africa with cattle from Tanzania in 1901 and, over the next 3 years, devastated the cattle that had survived the ...
T T Dolan
exaly   +3 more sources

Infection and treatment method (ITM) vaccine against East Coast fever: reducing the number of doses per straw for use in smallholder dairy herds by thawing, diluting and refreezing already packaged vaccine [PDF]

BMC Veterinary Research, 2019
Background The Infection and Treatment Method (ITM) of vaccination is the only immunization procedure currently available to protect cattle against East Coast fever (ECF), a tick-transmitted disease responsible for losses of several hundreds of millions ...
Ekta Patel, Stephen Mwaura, Giuseppe Di Giulio, Elizabeth A. J. Cook, Godelieve Lynen, Philip Toye   +5 more
doaj   +2 more sources

Rhipicephalus appendiculatus ticks transmit Theileria parva from persistently infected cattle in the absence of detectable parasitemia: implications for East Coast fever epidemiology [PDF]

Parasites & Vectors, 2018
Background East Coast fever (ECF) is a devastating disease of cattle and a significant constraint to improvement of livestock production in sub-Saharan Africa.
Cassandra L. Olds, Kathleen L. Mason, Glen A. Scoles   +2 more
doaj   +2 more sources

Comparison of the in vitro infectivity of different strains of Theileria parva in the Muguga cocktail vaccine [PDF]

Parasitology
Theileria parva, a protozoan parasite, is the causative agent of East Coast fever (ECF), an economically important disease of cattle in sub-Saharan Africa. The Muguga cocktail vaccine which comprises 3 T.
Wanangwa Mhonjo, George Chaka, Ekta Patel, Henson Kainga, Thoko Kapalamula, Ryo Nakao, Kyouko Hayashida, Elisha Chatanga   +7 more
doaj   +2 more sources

Flow Cytometric Analysis of the Cytotoxic T-Cell Recall Response to Theileria parva in Cattle Following Vaccination by the Infection and Treatment Method

Veterinary Sciences, 2021
The apicomplexan hemoparasite, Theileria parva, causes East Coast fever (ECF), a frequently fatal disease of African cattle. Vaccine development has been impeded by incomplete understanding of protective immunity following natural exposure or the ...
Mahmoud M. Elnaggar, Donald P. Knowles, William C. Davis, Lindsay M. Fry   +3 more
doaj   +1 more source