Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies. [PDF]
Su X, Tan Q, Zheng L, Ding Z.
europepmc +1 more source
Can Hormonal Therapy Improve the Outcomes of mTESE in Patients With Non‐Obstructive Azoospermia?
ABSTRACT Background Non‐obstructive azoospermia (NOA) represents the most severe form of male infertility. Hypogonadism is common in NOA patients, and normal testosterone (T) levels are considered essential for spermatogenesis. Fertility‐preserving hormonal therapy (FpHT) has been proposed to optimize hormonal milieu and improve sperm retrieval rates ...
Mattia Anfosso +5 more
wiley +1 more source
Intermediate clinical endpoints as surrogates for overall survival after salvage prostatectomy
Objectives To evaluate biochemical recurrence‐free survival (BRFS) and metastasis‐free survival (MFS) as potential intermediate clinical endpoints (ICEs) for overall survival (OS) in patients undergoing salvage radical prostatectomy (sRP). Patients and Methods Evaluable patients were selected from a retrospective dataset, resulting in a cohort of 879 ...
Navid Roessler +22 more
wiley +1 more source
WeCare intervention to improve breast cancer screening and research preparedness in rural and low-socioeconomic women: study protocol for a community-engaged feasibility trial. [PDF]
Sharma P +17 more
europepmc +1 more source
STHLM3 NorDCaP: prospective multicentre trial of Stockholm3 for active surveillance biopsy guidance
Objectives Active surveillance (AS) is the preferred approach for low‐risk prostate cancer (PCa). Recent efforts have explored new biomarkers to reduce the frequency of surveillance biopsy. This study assessed Stockholm3 for predicting PCa upgrading during surveillance biopsies. Materials and Methods The prospective STHLM3‐AS NorDCaP trial included 199
Nicola Giudici +11 more
wiley +1 more source
Integrated omics reveal the effects of vitamin D deficiency on gut microbiota and plasma metabolism in experimental autoimmune uveitis. [PDF]
Chen Z +6 more
europepmc +1 more source
Abstract Near‐surface wind regimes govern critical Earth system processes including dust mobilization, ocean mixing, and wildfire spread, yet their multi‐decadal evolution under anthropogenic forcing remains poorly constrained. Here we quantify extreme wind frequency changes (1981–2024) using ERA5‐Land reanalysis with a monthly aggregation approach ...
Adil Salhi, Essam Heggy
wiley +1 more source
A plasmonic metasurface comprising gold cylinders of tailored dimensions exhibits simultaneously the generalized Kerker effect and a bound state in the continuum, allowing for a detailed study of the subtle interplay between these phenomena. The numerical simulation results are in good agreement with experimental measurements, and the underlying ...
Sergejs Boroviks +4 more
wiley +1 more source
Navigating the tension between missed diagnosis and overdiagnosis: A comparison of the recent Chinese Urological Association and European Association of Urology guidelines on prostate biopsy. [PDF]
Ji J, Shen X, Zhou Z, Gao X.
europepmc +1 more source
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets +4 more
wiley +1 more source

