Results 1 to 10 of about 1,555 (179)

The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis [PDF]

Journal of Immunology Research, 2016
The microbiota is a crucial modulator of the immune system. Here, we evaluated how its absence or reduction modifies the inflammatory response in the murine model of experimental autoimmune uveoretinitis (EAU).
Jarmila Heissigerova, Petra Seidler Stangova, Aneta Klimova, Petra Svozilkova, Tomas Hrncir, Renata Stepankova, Miloslav Kverka, Helena Tlaskalova-Hogenova, John V. Forrester   +8 more
doaj   +6 more sources

The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis. [PDF]

PLoS ONE, 2015
Macrophage activation is, in part, regulated via hydrolysis of oxidised low density lipoproteins by Lipoprotein-Associated phospholipase A2 (Lp-PLA2), resulting in increased macrophage migration, pro-inflammatory cytokine release and chemokine expression.
G L Crawford, J Boldison, D A Copland, P Adamson, D Gale, M Brandt, L B Nicholson, A D Dick   +7 more
doaj   +3 more sources

IFN-β inhibits the increased expression of IL-9 during experimental autoimmune uveoretinitis. [PDF]

PLoS ONE, 2012
PurposeIt has been shown that IL-9 plays a proinflammatory role in the pathogenesis of certain autoimmune diseases. This study was designed to investigate the possible role of IL-9 in the development of experimental autoimmune uveoretinitis (EAU) and the
Yan Yang, Liping Du, Min Sun, Aize Kijlstra, Peizeng Yang   +4 more
doaj   +3 more sources

Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells. [PDF]

PLoS ONE, 2014
Experimental autoimmune uveoretinitis (EAU) is an organ-specific T cell-mediated disease induced by immunizing mice with interphotoreceptor retinoid binding protein (IRBP). Autoaggressive CD4(+) T cells are the major pathogenic population for EAU.
Zaied Ahmed Bhuyan, Michihito Asanoma, Akiko Iwata, Chieko Ishifune, Yoichi Maekawa, Mitsuo Shimada, Koji Yasutomo   +6 more
doaj   +5 more sources

Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography. [PDF]

PLoS ONE, 2013
Despite advances in clinical imaging and grading our understanding of retinal immune responses and their morphological correlates in experimental autoimmune uveoretinitis (EAU), has been hindered by the requirement for post-mortem histology.
Colin J Chu, Philipp Herrmann, Livia S Carvalho, Sidath E Liyanage, James W B Bainbridge, Robin R Ali, Andrew D Dick, Ulrich F O Luhmann   +7 more
doaj   +4 more sources

Metabolic profile analysis of free amino acids in experimental autoimmune uveoretinitis rat plasma [PDF]

International Journal of Ophthalmology, 2019
AIM: To determine the differences of amino acid (AA) levels in experimental autoimmune uveoretinitis (EAU). METHODS: AA analysis of the plasma samples in EAU rats induced by interphotoreceptor retinoid-binding protein emulsion were performed with high ...
Jun-Guo Guo, Xin-Miao Guo, Xing-Rong Wang, Jing-Zhen Tian, Hong-Sheng Bi   +4 more
doaj   +2 more sources

Crystallin β-b2 promotes retinal ganglion cell protection in experimental autoimmune uveoretinitis [PDF]

Frontiers in Cellular Neuroscience
Crystallin βb2 (crybb2) is upregulated in regenerating retinas and in various pathological conditions of the retina, including uveoretinitis. However, the role of crybb2 in this disease is largely unknown.
Dirk Bauer, Michael R. R. Böhm, Michael R. R. Böhm, Michael R. R. Böhm, Xiaoyu Wu, Bo Wang, Tida Viola Jalilvand, Tida Viola Jalilvand, Martin Busch, Maren Kasper, Katrin Brockhaus, Katrin Brockhaus, Lena Wildschütz, Harutyun Melkonyan, Björn Laffer, Gerd Meyer Zu Hörste, Arnd Heiligenhaus, Arnd Heiligenhaus, Solon Thanos   +18 more
doaj   +2 more sources

Anti-inflammatory actions of ripasudil ameliorate experimental autoimmune uveoretinitis in the acute phase [PDF]

BMJ Open Ophthalmology
Introduction Rho-associated protein kinases (ROCKs) are a key regulator of T cell function, influencing a wide range of processes from activation to differentiation.
Tomohito Sato, Masaru Takeuchi, Kozo Harimoto, Hideaki Someya, Masataka Ito, Yoshiaki Nishio   +5 more
doaj   +2 more sources

AAV2-mediated subretinal gene transfer of mIL-27p28 attenuates experimental autoimmune uveoretinitis in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Advances in gene transfer techniques have provided long-term, safe and stable transduction of retinal cells following subretinal injection with adeno-associated viral (AAV) vectors.
Ju Shao, Lichun Tian, Bo Lei, Lin Wei, Yan Yang, Aize Kijlstra, Peizeng Yang   +6 more
doaj   +2 more sources

Treatment of experimental autoimmune uveoretinitis with different natural compounds. [PDF]

Mol Med Rep, 2016
Uveitis is an important eye disease that potentially causes loss of sight. Although extensive studies have been conducted on uveitis, the exact pathogenesis remains to be determined. The effects of treatment with natural compounds on an experimental autoimmune uveoretinitis (EAU) rat model were examined in the present study.
Li M, Chen X, Liu J, Wang D, Gan L, Lv X, Qiao Y.   +6 more
europepmc   +4 more sources