Results 11 to 20 of about 1,306 (146)

AAV2-mediated subretinal gene transfer of hIFN-α attenuates experimental autoimmune uveoretinitis in mice. [PDF]

PLoS ONE, 2011
BackgroundRecent reports show that gene therapy may provide a long-term, safe and effective intervention for human diseases. In this study, we investigated the effectiveness of adeno-associated virus 2 (AAV2) based human interferon-alpha (hIFN-α) gene ...
Lichun Tian, Peizeng Yang, Bo Lei, Ju Shao, Chaokui Wang, Qin Xiang, Lin Wei, Zhougui Peng, Aize Kijlstra   +8 more
doaj   +2 more sources

Kinetic changes in microglia-related retinal transcripts in experimental autoimmune uveoretinitis (EAU) of B10.RIII mice [PDF]

Journal of Neuroinflammation
In this study the retinal transcriptome was investigated during the development of experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced by immunizing B10.RIII mice with human interphotoreceptor retinoid binding protein (hIRBP) 161–180 ...
Maren Kasper, Marcus Karlstetter, Lena Wildschütz, Rebecca Scholz, Martin Busch, Dirk Bauer, Gerd Meyer zu Hörste, Solon Thanos, Thomas Langmann, Arnd Heiligenhaus   +9 more
doaj   +2 more sources

Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells [PDF]

International Journal of Ophthalmology, 2015
AIM:To determine the effects of rapamycin on experimental autoimmune uveoretinitis (EAU) and investigate of role of rapamycin on T cell subsets in the disease.
Li-Fei Yuan, Guang-Da Li, Xin-Jun Ren, Hong Nian, Xiao-Rong Li, Xiao-Min Zhang   +5 more
doaj   +2 more sources

Regulatory effects of IFN-β on the development of experimental autoimmune uveoretinitis in B10RIII mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases.
Min Sun, Yan Yang, Peizeng Yang, Bo Lei, Liping Du, Aize Kijlstra   +5 more
doaj   +2 more sources

Immunopathology of Experimental Autoimmune Uveoretinitis in Primates

Autoimmunity, 1992
The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed moderate to marked uveoretinitis ...
Chi-Chao Chan, Igal Very, Hum Chung
exaly   +3 more sources

Enhanced M2 Polarization of Retinal Microglia in Streptozotocin-Induced Diabetic Mice upon Autoimmune Stimulation [PDF]

Biomedicines
Background: This study aimed to investigate the impact of the diabetic environment on the development of experimental autoimmune uveoretinitis (EAU) and the activation status of microglia in the eye.
Yoshiaki Nishio, Hideaki Someya, Kozo Harimoto, Tomohito Sato, Masataka Ito, Masaru Takeuchi   +5 more
doaj   +2 more sources

AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis. [PDF]

PLoS ONE, 2012
We previously showed that adeno-associated virus 2 (AAV2) mediated subretinal delivery of human interferon-alpha (IFN-α) could effectively inhibit experimental autoimmune uveoretinitis (EAU).
Lichun Tian, Bo Lei, Ju Shao, Lin Wei, Aize Kijlstra, Peizeng Yang   +5 more
doaj   +2 more sources

Tissue resident memory T cells populate the human uveal tract [PDF]

Scientific Reports
The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues.
Andrew D. Foers, Ian R. Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas MW. Buckley, Moustafa Attar, Soledad Aguilar-Munoa, Queen Pilapil, Maram EA. Abdalla Elsayed, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Kin Sheng Lim, Mark C. Coles, Jonathan P. Sherlock, Andrew D. Dick, Sarah E. Coupland, Stephen N. Sansom, David A. Copland, Christopher D. Buckley, Srilakshmi M. Sharma, ORBIT Consortium   +25 more
doaj   +3 more sources

Biopotency and surrogate assays to validate the immunomodulatory potency of extracellular vesicles derived from mesenchymal stem/stromal cells for the treatment of experimental autoimmune uveitis

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have been recognized as promising cytotherapeutics due to their demonstrated immunomodulatory effects in various preclinical models.
Gagandeep Kaur, Eun‐Hye Bae, Yu Zhang, Nicole Ciacciofera, Kyung Min Jung, Heather Barreda, Carol Paleti, Joo Youn Oh, Ryang Hwa Lee   +8 more
doaj   +2 more sources

Chitosan Oligosaccharides Suppress Nuclear Factor-Kappa B Activation and Ameliorate Experimental Autoimmune Uveoretinitis in Mice. [PDF]

Int J Mol Sci, 2020
Hsu SM, Yang CH, Tsai HY, Lin CJ, Fang YH, Shieh CC, Chen SH.   +6 more
europepmc   +2 more sources