Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells [PDF]
International Journal of Ophthalmology, 2015 AIM:To determine the effects of rapamycin on experimental autoimmune uveoretinitis (EAU) and investigate of role of rapamycin on T cell subsets in the disease.
Li-Fei Yuan +5 more
doaj +3 more sources
Stem Cell Reports, 2017 Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models.
Taeko Shigemoto-Kuroda +10 more
doaj +4 more sources
AAV2-mediated subretinal gene transfer of hIFN-α attenuates experimental autoimmune uveoretinitis in mice. [PDF]
PLoS ONE, 2011 BackgroundRecent reports show that gene therapy may provide a long-term, safe and effective intervention for human diseases. In this study, we investigated the effectiveness of adeno-associated virus 2 (AAV2) based human interferon-alpha (hIFN-α) gene ...
Lichun Tian +8 more
doaj +3 more sources
Kinetic changes in microglia-related retinal transcripts in experimental autoimmune uveoretinitis (EAU) of B10.RIII mice [PDF]
Journal of NeuroinflammationIn this study the retinal transcriptome was investigated during the development of experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced by immunizing B10.RIII mice with human interphotoreceptor retinoid binding protein (hIRBP) 161–180 ...
Maren Kasper +9 more
doaj +2 more sources
Regulatory effects of IFN-β on the development of experimental autoimmune uveoretinitis in B10RIII mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases.
Min Sun +5 more
doaj +2 more sources
Immunopathology of Experimental Autoimmune Uveoretinitis in Primates
Autoimmunity, 1992 The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed moderate to marked uveoretinitis ...
Yujiro Fujino +2 more
exaly +3 more sources
Enhanced M2 Polarization of Retinal Microglia in Streptozotocin-Induced Diabetic Mice upon Autoimmune Stimulation [PDF]
BiomedicinesBackground: This study aimed to investigate the impact of the diabetic environment on the development of experimental autoimmune uveoretinitis (EAU) and the activation status of microglia in the eye.
Yoshiaki Nishio +5 more
doaj +2 more sources
AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis. [PDF]
PLoS ONE, 2012 We previously showed that adeno-associated virus 2 (AAV2) mediated subretinal delivery of human interferon-alpha (IFN-α) could effectively inhibit experimental autoimmune uveoretinitis (EAU).
Lichun Tian +5 more
doaj +2 more sources
Tfh Cells in Henoch-Schönlein Purpura (IgA Vasculitis): Current Concept. [PDF]
J Immunol ResHenoch‐Schönlein purpura (HSP) is an inflammatory condition affecting the small blood vessels, leading to organ damage and symptoms across various body systems, including skin, joints, and kidneys. The disease’s pathogenesis involves the deposition of immunoglobulin (Ig) A immune complexes in vessels, triggering inflammation and damage. Recent research
Huang J, Liu J, Hu Y, Zhang X, Zhang Q.
europepmc +2 more sources
Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease. [PDF]
Immun Inflamm DisGroup A streptococcal M protein elicit antibody and T‐cell responses that cross react with cardiac and connective tissue proteins in the Rat Autoimmune Valvulitis (RAV) model of rheumatic heart disease. Bordetella pertussis Toxin induce a robust Th1 response that potentiates the autoimmune process in the RAV model A robust Th1/Th17 response was found ...
Rafeek RAM +6 more
europepmc +2 more sources