Results 41 to 50 of about 1,555 (179)

Role of Janus Kinase (JAK) Inhibitor in Autoimmune Ocular Inflammation: A Systematic Review

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Purpose. To evaluate the effectiveness of Janus kinase (JAK) inhibitors for the treatment of patients with autoimmune disease and associated inflammatory ocular diseases. Methods. We identified relevant literature by screening the MEDLINE, PubMed, and Cochrane databases for randomized controlled trials, cohort studies, case controls, and case reports ...
Ji Wen, Huifang Hu, Menglin Chen, Hang Yang, Yi Zhao, Yi Liu, Chiara Posarelli   +6 more
wiley   +1 more source

A Role for Folate in Microbiome‐Linked Control of Autoimmunity

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis.
Christine Mölzer, Heather M. Wilson, Lucia Kuffova, John V. Forrester, Mingyi Zhao   +4 more
wiley   +1 more source

Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]

, 2008
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Amann, B., Amann, Barbara, Raith, A., Ueffing, Marius, Pompetzki, D., Schmalzl, T., Altmann, Frank, Hauck, S.M., Ueffing, M., Pompetzki, Dirk, Schmalzl, Thomas, Stangassinger, Manfred, Stangassinger, M., Altmann, F., Deeg, Cornelia A., Hauck, Stefanie M., Raith, Albert, Deeg, C.A.   +17 more
core   +1 more source

Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling. [PDF]

PLoS ONE, 2013
IL-17-producing CD4(+) T helper 17 (Th17) cells are pathogenic in a range of human autoimmune diseases and corresponding animal models. We now demonstrate that such T cells infiltrating the target organ during the induction of experimental autoimmune ...
Ben J E Raveney, Shinji Oki, Takashi Yamamura   +2 more
doaj   +1 more source

Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. [PDF]

, 2011
Autoimmune uveitis is an intraocular inflammation that arises through autoreactive T-cells attacking the inner eye, eventually leading to blindness. However, the contributing molecular pathomechanisms within the affected tissues remain as yet elusive ...
Cornelia A. Deeg, Amann, B., Amann, Barbara, Hofmaier, F., Eberhardt Christina, Hauck Stefanie M., Barbara Amann, Hofmaier Florian, Christina Eberhardt, Florian Hofmaier, Eberhardt, Christina, Hauck, S.M., Cornelia A Deeg, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Hauck, Stefanie M., Eberhardt, C., Hofmaier, Florian, Deeg, C.A.   +21 more
core   +1 more source

Osteopontin is a biomarker for early autoimmune uveoretinitis

Neural Regeneration Research, 2022
Osteopontin (OPN) is an extracellular matrix protein with a diverse range of functions, including roles in cell adhesion, migration, and immunomodulation, which are associated with the modulation of neuroinflammation in the central nervous system.
Jeongtae Kim, Meejung Ahn, Yuna Choi, Jiyoon Chun, Kyungsook Jung, Akane Tanaka, Hiroshi Matsuda, Taekyun Shin   +7 more
doaj   +1 more source

Prevention of Experimental Autoimmune Uveoretinitis by Vasoactive IntestinalPeptide [PDF]

Archives of Ophthalmology, 2004
Vasoactive intestinal peptide (VIP), a neuropeptide that is known to be present in lymphoid tissue microenvironments, shows prominent anti-inflammatory actions.To examine the potential effect of VIP on the development of experimental autoimmune uveoretinitis (EAU).We immunized C57BL/6 mice with human interphotoreceptor retinoid-binding protein peptide ...
Hiroshi, Keino, Takeshi, Kezuka, Masaru, Takeuchi, Naoyuki, Yamakawa, Takaaki, Hattori, Masahiko, Usui   +5 more
openaire   +2 more sources

Anti‐inflammatory and immune‐modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation

Journal of Cellular and Molecular Medicine, Volume 24, Issue 23, Page 13573-13588, December 2020., 2020
Abstract Autoreactive inflammatory CD4+ T cells, such as T helper (Th)1 and Th17 subtypes, have been found to associate with the pathogenesis of autoimmune disorders. On the other hand, CD4+ Foxp3+ T regulatory (Treg) cells are crucial for the immune tolerance and have a critical role in the suppression of the excessive immune and inflammatory response
Seyed‐Morteza Ehteshamfar, Masoume Akhbari, Jalil Tavakol Afshari, Motahareh Seyedi, Banafsheh Nikfar, Abbas Shapouri‐Moghaddam, Erfan Ghanbarzadeh, Amir Abbas Momtazi‐Borojeni   +7 more
wiley   +1 more source

An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils

The FASEB Journal, Volume 34, Issue 7, Page 9316-9336, July 2020., 2020
Abstract The lens and central cornea are avascular. It was assumed that the adult lens had no source of immune cells and that the basement membrane capsule surrounding the lens was a barrier to immune cell migration. Yet, microfibril‐associated protein‐1 (MAGP1)‐rich ciliary zonules that originate from the vasculature‐rich ciliary body and extend along
JodiRae DeDreu, Caitlin J. Bowen, Caitlin M. Logan, Sonali Pal‐Ghosh, Paola Parlanti, Mary Ann Stepp, A. Sue Menko   +6 more
wiley   +1 more source

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

FEBS Open Bio, Volume 10, Issue 6, Page 969-978, June 2020., 2020
Autoimmune pancreatitis frequently causes acute episodes with clinical symptoms parallel to those of acute pancreatitis. Due to their significant immunomodulatory capabilities, mesenchymal stromal cells (MSCs) have been proposed as a novel treatment strategy for various immune and inflammatory pathologies including those with autoimmune origins.
Robbie R. Goodman, John E. Davies
wiley   +1 more source