Results 51 to 60 of about 1,555 (179)

Mesenchymal stem cells‐derived exosomes improve pregnancy outcome through inducing maternal tolerance to the allogeneic fetus in abortion‐prone mating mouse

The Kaohsiung Journal of Medical Sciences, Volume 36, Issue 5, Page 363-370, May 2020., 2020
Abstract Recurrent pregnancy loss (RPL) is three or more times of consecutive spontaneous loss of pregnancy. The underlying cause is complicated and the etiology of over 50% of RPL patients is unclear. In the present study, bone marrow mesenchymal stem cells were isolated from CBA/J female mice and exosomes were isolated from cell culture medium by ...
Yan‐Jie Xiang, Yan‐Yan Hou, Hong‐Li Yan, Hui Liu, Yan‐Xin Ge, Na Chen, Jian‐Feng Xiang, Cui‐Fang Hao   +7 more
wiley   +1 more source

Macrophages and Uveitis in Experimental Animal Models

Mediators of Inflammation, 2015
Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In
Salvador Mérida, Elena Palacios, Amparo Navea, Francisco Bosch-Morell   +3 more
doaj   +1 more source

CD4+CCR6+ T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice

European Journal of Immunology, Volume 50, Issue 2, Page 245-255, February 2020., 2020
Abstract IL‐23 plays an important role in the development of arthritis and the IL‐23 receptor (IL‐23R) is expressed on different types of T cells. However, it is not fully clear which IL‐23R+ T cells are critical in driving T cell‐mediated synovitis. We demonstrate, using knock‐in IL‐23R‐GFP reporter (IL‐23RGFP/+) mice, that CD4+CCR6+ T cells and γδ T 
Wida Razawy, Patrick S. Asmawidjaja, Anne‐Marie Mus, Nazike Salioska, Nadine Davelaar, Nicole Kops, Mohamed Oukka, C. Henrique Alves, Erik Lubberts   +8 more
wiley   +1 more source

Suppressive effects of a novel compound on interphotoreceptor retinoid-binding protein-induced experimental autoimmune uveoretinitis in rats

Allergology International, 1999
The immunosuppressive effect of ethyl O-(N-(pcarboxyphenyl)-carbamoyl)-mycophenolate(CAM) was examined in interphotoreceptor retinoid-binding protein (IRBP)-induced experimental autoimmune uveoretinitis (EAU) in rats.
Jun-ichi Sakai, Takeshi Kezuka, Hidetoshi Yokoi, Annabelle A Okada, Masahiko Usui, Junichiro Mizuguchi, Yutaro Kaneko   +6 more
doaj   +1 more source

Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. [PDF]

PLoS ONE, 2012
The small heat shock protein, αA-crystallin null (αA-/-) mice are known to be more prone to retinal degeneration than the wild type mice in Experimental Autoimmune Uveoretinitis (EAU).
Narsing A Rao, Sindhu Saraswathy, Geeta Pararajasegaram, Suraj P Bhat   +3 more
doaj   +1 more source

Autoimmune and autoinflammatory mechanisms in uveitis

, 2014
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult ...
Dick, Andrew D, Robert B. Nussenblatt, Wei, Lai, Dick, AD, Andrew D. Dick, Nicholson, Lindsay B, Chan, Chi-Chao, Lindsay B. Nicholson, Sen, H Nida, Wei, L, H. Nida Sen, Nussenblatt, RB, Nicholson, LB, Chi-Chao Chan, Lee, RW, Nussenblatt, Robert B, Sen, HN, Richard W. Lee, Lai Wei, Chan, CC, Lee, Richard W   +20 more
core   +1 more source

ISEV2023 Abstract Book

, 2023
Journal of Extracellular Vesicles, Volume 12, Issue S1, May 2023.
wiley   +1 more source

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target [PDF]

, 2012
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (TFH) in the ...
Chakera, Aron, Bowness, Paul, Raashid A. Luqmani, Morteau, O, Luqmani, Raashid, Bennett, S., Richard J. Cornall, Bowness, P., Luqmani, Raashid A, Bennett, Sophia C, Morteau, O., Aron Chakera, Sophia C. Bennett, Paul Bowness, Morteau, Olivier, Cornall, Richard J, Bennett, SC, Olivier Morteau, Cornall, R., Cornall, Richard, Chakera, A, Luqmani, R.   +21 more
core   +1 more source

Sialoadhesin Promotes the Inflammatory Response in Experimental Autoimmune Uveoretinitis [PDF]

The Journal of Immunology, 2006
Abstract Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced ...
Hui-Rong, Jiang, Lenias, Hwenda, Kimmo, Makinen, Cornelia, Oetke, Paul R, Crocker, John V, Forrester   +5 more
openaire   +2 more sources

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease

, 2009
Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Yang, P.Z., Du, L.P., Zhao, C.L., Lin, X.M., He, H., Zhou, H.Y., Kijlstra, A.   +6 more
core   +1 more source