Results 51 to 60 of about 2,739 (187)

An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils

The FASEB Journal, Volume 34, Issue 7, Page 9316-9336, July 2020., 2020
Abstract The lens and central cornea are avascular. It was assumed that the adult lens had no source of immune cells and that the basement membrane capsule surrounding the lens was a barrier to immune cell migration. Yet, microfibril‐associated protein‐1 (MAGP1)‐rich ciliary zonules that originate from the vasculature‐rich ciliary body and extend along
JodiRae DeDreu, Caitlin J. Bowen, Caitlin M. Logan, Sonali Pal‐Ghosh, Paola Parlanti, Mary Ann Stepp, A. Sue Menko   +6 more
wiley   +1 more source

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

FEBS Open Bio, Volume 10, Issue 6, Page 969-978, June 2020., 2020
Autoimmune pancreatitis frequently causes acute episodes with clinical symptoms parallel to those of acute pancreatitis. Due to their significant immunomodulatory capabilities, mesenchymal stromal cells (MSCs) have been proposed as a novel treatment strategy for various immune and inflammatory pathologies including those with autoimmune origins.
Robbie R. Goodman, John E. Davies
wiley   +1 more source

Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models [PDF]

, 2016
Myeloid cells make a pivotal contribution to tissue homeostasis during inflammation. Both tissue-specific resident populations and infiltrating myeloid cells can cause tissue injury through aberrant activation and/or dysregulated activity.
Ali, RR, Bainbridge, JW, Cristante, E, Gardner, PJ, Liyanage, SE, Luhmann, UFO, Ribeiro, J, Sampson, RD   +7 more
core   +1 more source

Mesenchymal stem cells‐derived exosomes improve pregnancy outcome through inducing maternal tolerance to the allogeneic fetus in abortion‐prone mating mouse

The Kaohsiung Journal of Medical Sciences, Volume 36, Issue 5, Page 363-370, May 2020., 2020
Abstract Recurrent pregnancy loss (RPL) is three or more times of consecutive spontaneous loss of pregnancy. The underlying cause is complicated and the etiology of over 50% of RPL patients is unclear. In the present study, bone marrow mesenchymal stem cells were isolated from CBA/J female mice and exosomes were isolated from cell culture medium by ...
Yan‐Jie Xiang, Yan‐Yan Hou, Hong‐Li Yan, Hui Liu, Yan‐Xin Ge, Na Chen, Jian‐Feng Xiang, Cui‐Fang Hao   +7 more
wiley   +1 more source

Rhodopsin-induced experimental autoimmune uveoretinitis in monkeys. [PDF]

British Journal of Ophthalmology, 1989
We present the first evidence that purified rhodopsin can induce experimental autoimmune uveoretinitis (EAU) in monkeys. Injection of a highly purified lipid-free rhodopsin preparation provokes severe chorioretinitis with concomitant anterior uveitis.
J J, Schalken, H J, Winkens, A H, Van Vugt, W J, De Grip, R M, Broekhuyse   +4 more
openaire   +2 more sources

Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]

, 2008
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Altmann, Frank, Amann, Barbara, Deeg, Cornelia A., Hauck, Stefanie M., Pompetzki, Dirk, Raith, Albert, Schmalzl, Thomas, Stangassinger, Manfred, Ueffing, Marius   +8 more
core   +1 more source

CD4+CCR6+ T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice

European Journal of Immunology, Volume 50, Issue 2, Page 245-255, February 2020., 2020
Abstract IL‐23 plays an important role in the development of arthritis and the IL‐23 receptor (IL‐23R) is expressed on different types of T cells. However, it is not fully clear which IL‐23R+ T cells are critical in driving T cell‐mediated synovitis. We demonstrate, using knock‐in IL‐23R‐GFP reporter (IL‐23RGFP/+) mice, that CD4+CCR6+ T cells and γδ T 
Wida Razawy, Patrick S. Asmawidjaja, Anne‐Marie Mus, Nazike Salioska, Nadine Davelaar, Nicole Kops, Mohamed Oukka, C. Henrique Alves, Erik Lubberts   +8 more
wiley   +1 more source

Macrophages and Uveitis in Experimental Animal Models

Mediators of Inflammation, 2015
Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In
Salvador Mérida, Elena Palacios, Amparo Navea, Francisco Bosch-Morell   +3 more
doaj   +1 more source

Stochastic effects in autoimmune dynamics [PDF]

, 2018
Among various possible causes of autoimmune disease, an important role is played by infections that can result in a breakdown of immune tolerance, primarily through the mechanism of ``molecular mimicry".
Alexander, Allen, Allen, Allen, Alonso, Altan-Bonnet, Antia, Bartels, Ben Ezra, Bitmansour, Black, Black, Black, Blattman, Blyuss, Blyuss, Boldison, Borghans, Borghans, Brauer, Braumann, Bruna, Burroughs, Burroughs, Burroughs, Carneiro, Chao, Conway, Davies, Deenick, Detours, Earnest, Ercolini, Fujinami, Gardiner, Gillespie, Gillespie, Grossman, Grossman, Grossman, Hammarling, Hayot, Hufton, Iwami, Iwami, Kerr, Kuske, León, León, León, Mandal, McKane, Neofytou, Nicholson, Noest, Nylander, Pahle, Perelson, Prat, Reynolds, Root-Bernstein, Römer, Santamaria, Scherer, Segel, Skapenko, Stefanova, Stirk, Stirk, van den Berg, van Kampen, von Herrath, Wallace, Wolf, Wu, Yuan, Øksendal   +76 more
core   +3 more sources

Lipoprotein‐associated phospholipase A2: The story continues

Medicinal Research Reviews, Volume 40, Issue 1, Page 79-134, January 2020., 2020
Abstract Inflammation is thought to play an important role in the pathogenesis of vascular diseases. Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) mediates vascular inflammation through the regulation of lipid metabolism in blood, thus, it has been extensively investigated to identify its role in vascular inflammation‐related diseases, mainly ...
Fubao Huang, Kai Wang, Jianhua Shen
wiley   +1 more source