Results 1 to 10 of about 16,678 (173)
Nest-building behaviour in male rats from three inbred strains: BN/HsdCpb, BDIX/Or1Ico and LEW/Mol
Animal Welfare, 2005 AbstractThree inbred strains of male laboratory rat (BN/HsdCpb, BDIX/Or1Ico and LEW/Mol) were provided with nest boxes and nest materials, and were observed for nest-building activity. After 7 days, each cage and nest box was examined. Each nest was weighed and scored for complexity, and returned to the cage.
IM Jegstrup +3 more
openaire +2 more sources
Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor [PDF]
Behavioral and Brain Functions, 2007 Rodents are known to display fear-related responses when exposed to the odor of natural predators, such as cats, even when they are totally naïve to these stimuli.
Ramos André +2 more
doaj +2 more sources
Behavioral and Brain Functions, 2006 Background Attention deficit hyperactivity disorder (ADHD) is a complex neuropsychiatric disorder with a substantial genetic component. The Spontaneously Hypertensive Rats (SHR), considered as a good animal model of ADHD, also show less anxiety-like ...
Ramos André +5 more
doaj +2 more sources
Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet [PDF]
Disease Models & Mechanisms, 2016 Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are ...
Neus Martínez-Micaelo +7 more
doaj +2 more sources
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +2 more sources
N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat. [PDF]
PLoS ONE, 2012 Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopamine ...
Charalambos Tsagogiorgas +14 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2010 Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease.
Juliana Seger +5 more
doaj +1 more source
Zinc-finger nuclease mediated disruption of
BMC Immunology, 2012 Background Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or ...
Zschemisch Nils-Holger +6 more
doaj +1 more source
Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert +15 more
doaj +1 more source
Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction
BMC Pharmacology and Toxicology, 2017 Background Focal hepatic venous outflow obstruction frequently occurs after extended liver resection and leads to a portal hypertension, arterial hypoperfusion and parenchymal necrosis.
J. Arlt +6 more
doaj +1 more source