Results 11 to 20 of about 750,094 (133)

Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor

open access: yesBehavioral and Brain Functions, 2007
Rodents are known to display fear-related responses when exposed to the odor of natural predators, such as cats, even when they are totally naïve to these stimuli.
Ramos André   +2 more
doaj   +1 more source

Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats

open access: yesMemorias do Instituto Oswaldo Cruz, 2010
Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease.
Juliana Seger   +5 more
doaj   +1 more source

Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

open access: yesBMC Immunology, 2012
Background Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or ...
Zschemisch Nils-Holger   +6 more
doaj   +1 more source

Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert   +15 more
doaj   +1 more source

Hyperinsulinemic LEW.1WR1 rats develop insulin resistance and nonalcoholic steatohepatitis

open access: yes, 2023
The pathophysiological causes of nonalcoholic steatohepatitis (NASH) development are not fully understood but are often associated with hyperinsulinemia, insulin resistance and ectopic lipid accumulation.
Wimalarathne, Madushika M.
core   +1 more source

Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction

open access: yesBMC Pharmacology and Toxicology, 2017
Background Focal hepatic venous outflow obstruction frequently occurs after extended liver resection and leads to a portal hypertension, arterial hypoperfusion and parenchymal necrosis.
J. Arlt   +6 more
doaj   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]

open access: yes, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris   +17 more
core   +1 more source

Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.

open access: yes, 2004
We recently identified a single-nucleotide polymorphism in the Ncf1 gene, a component of the NADPH oxidase complex, to be the cause of one of the strongest identified loci for arthritis severity in rats.
Dirk Wedekind   +21 more
core   +1 more source

Antibody response to mycobacterial hsp65 (Bhsp65) of Celastrus-fed Lewis (LEW) rats

open access: yes, 2011
Copyright information:Taken from "Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65"http://arthritis-research.com/content/9/4/R70Arthritis Research & Therapy 2007;9(4):R70-R70 ...
Kamal D Moudgil (84276), Li Tong (84275)
core   +1 more source

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