The use of FK-506 for small intestine llotransplantation: Inhibition of acute rejection and prevention of fatal graft-versus-host disease [PDF]
, 1990 Small intestine allotransplantation in humans is not yet feasible due to the failure of the current methods of immunosuppression. FK-506, a powerful new immunosuppressive agent that is synergistic with cyclosporine, allows long-term survival of ...
Banner, B +7 more
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Zinc-finger nuclease mediated disruption of
BMC Immunology, 2012 Background Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or ...
Zschemisch Nils-Holger +6 more
doaj +1 more source
Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert +15 more
doaj +1 more source
Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction
BMC Pharmacology and Toxicology, 2017 Background Focal hepatic venous outflow obstruction frequently occurs after extended liver resection and leads to a portal hypertension, arterial hypoperfusion and parenchymal necrosis.
J. Arlt +6 more
doaj +1 more source
Genetic loci for ventricular dilatation in the LEW/Jms rat with fetal-onset hydrocephalus are influenced by gender and genetic background [PDF]
, 2005 Background The LEW/Jms rat strain has inherited hydrocephalus, with more males affected than females and an overall expression rate of 28%. This study aimed to determine chromosomal positions for genetic loci causing the hydrocephalus.
Mayorga David A +4 more
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Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]
, 1994 Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Fujisaki, S +6 more
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Suppression of allograft rejection with FK506: I. prolonged cardiac and liver survival in rats following short-course therapy [PDF]
, 1990 Heterotopic heart and orthotopic liver grafts from ACI donors were transplanted to Lewis rat recipients that were treated with a 3 (or 4) day course of FK506 IM that was started on postoperative day 0, 2, 3, 4, 5, or 6.
Cramer, DV +5 more
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Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]
, 2015 We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul +16 more
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Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. [PDF]
, 1987 In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation.
Chapman, F +7 more
core
Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts. [PDF]
, 1996 Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were ...
Azuma, H. +5 more
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