Results 41 to 50 of about 16,678 (173)

Desenvolvimento de uma linhagem congênica para um locus no cromossomo 4 do rato com efeito sobre a emocionalidade [PDF]

, 2012
Tese(doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Farmacologia, Florianópolis, 2010Um intercruzamento entre as linhagens isogênicas de ratos Lewis (LEW) e espontaneamente hipertensos ...
Pereira, Elayne
core  

Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives

EFSA Journal, Volume 22, Issue 11, November 2024.
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Monika Batke, Ellen Bruzell, James Chipman, Karlien Cheyns, Riccardo Crebelli, Cristina Fortes, Peter Fürst, Thorhallur Halldorsson, Jean‐Charles LeBlanc, Manuela Mirat, Oliver Lindtner, Alicja Mortensen, Evangelia Ntzani, Romina Shah, Heather Wallace, Matthew Wright, Stefania Barmaz, Consuelo Civitella, Petra Georgelova, Federica Lodi, Elena Mazzoli, Josef Rasinger, Ana Maria Rincon, Alexandra Tard, Panagiota Zakidou, Maged Younes   +42 more
wiley   +1 more source

Caracterização fenotípica e molecular da linhagem congênica de ratos SHR.LEW-Anxrr16 como um novo modelo genético para o estudo da ansiedade [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaUm cruzamento entre as linhagens de ratos Lewis (LEW) e Spontaneously Hypertensive Rats (SHR) levou à identificação ...
Medeiros, Gabriela Ferreira de
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Effects of chronic administration and withdrawal of antidepressant agents on circadian activity rhythms in rats [PDF]

, 1992
Experimental and clinical studies indicate that clinical depression may be associated with disturbances of circadian rhythms. To explore the interaction between circadian rhythmicity, behavioral state, and monoaminergic systems, the present study ...
Wollnik, Franziska
core   +1 more source

Mouse developmental defects, but not paraganglioma tumorigenesis, upon conditional Complex II loss in early Sox10+ cells

FASEB BioAdvances, Volume 6, Issue 9, Page 327-336, September 2024.
In humans, paragangliomas (PGLs) form in certain neuroendocrine cells that have lost succinate dehydrogenase, an enzyme of the tricarboxylic acid cycle. Conditional SDH deficiency has not yet been shown to drive PGL formation in mice, limiting available research tools. Here, prenatal SDH knockout in small numbers of SOX10+ precursors of adrenal medulla
Elizabeth P. Lewis, Fatimah Al Khazal, Brandon Wilbanks, Naomi M. Gades, Patricia Ortega‐Sáenz, José López‐Barneo, Igor Adameyko, L. James Maher III   +7 more
wiley   +1 more source

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

Aging Cell, Volume 23, Issue 9, September 2024.
We tested if the effects of metformin were context specific in skeletal muscle using a rat model (high‐capacity and low‐capacity runners: HCRs/LCRs) with a divide in intrinsic aerobic capacity. Metformin lowered mitochondrial respiration, but a washout of metformin resulted in a doubling of respiratory capacity in HCRs, with no effect in LCRs.
Matthew P. Bubak, Arik Davidyan, Colleen L. O'Reilly, Samim A. Mondal, Jordan Keast, Stephen M. Doidge, Agnieszka K. Borowik, Michael E. Taylor, Evelina Volovičeva, Michael T. Kinter, Steven L. Britton, Lauren G. Koch, Michael B. Stout, Tommy L. Lewis Jr, Benjamin F. Miller   +14 more
wiley   +1 more source

Effects of Neonatal Handling on Play and Anxiety in F344 and Lewis Rats

, 2018
Play is an important part of normal childhood development and seen in many mammals, including rats. To better understand the interplay between genotype and postnatal experiences, the effects of neonatal handling on play were assessed in Lewis (LEW) and ...
Stephen M. Siviy, Siviy, Stephen M.
core   +1 more source

Adolescent cannabis exposure increases heroin reinforcement in rats genetically vulnerable to addiction

, 2020
On the basis of epidemiological studies it has been proposed that cannabis use plays a causal role in the abuse of highly addictive drugs (Gateway Hypothesis).
Scifo, Andrea, Valentini, Valentina, Cadoni, Cristina, Di Chiara, Gaetano, Piras, Giovanna, Sil, Annesha, Lecca, Daniele, Pisanu, Augusta   +7 more
core   +1 more source

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Animal Models and Experimental Medicine, Volume 7, Issue 3, Page 297-309, June 2024.
Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Yasodha Krishna Janapati, Sunil Junapudi
wiley   +1 more source

Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.

Japanese Journal of Pharmacology, 1987
Fischer 344 (F344), Lewis (LEW), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were chronically fed food containing pentobarbital on an escalating drug dosage schedule over a period of 47 days.
Tsutomu Suzuki, Tsutomu Suzuki, Tsutomu Suzuki, Y. Koike, Saizo Yanaura, Frank R. George, Frank R. George, R. Meisch   +7 more
semanticscholar   +1 more source