Results 41 to 50 of about 18,266 (185)

Stress sensitivity and cutaneous sensory thresholds before and after neuropathic injury in various inbred and outbred rat strains.

Behavioural Brain Research, 2019
Chronic pain is associated with altered affective state, stress, anxiety and depression. Conversely, stress, anxiety and depression can all modulate pain perception.
Sara Hestehave, K. Abelson, Tina Brønnum Pedersen, G. Munro   +3 more
semanticscholar   +1 more source

A novel small molecule phagocytosis inhibitor, KB‐208, ameliorates ITP in mouse models with similar efficacy as IVIG

Transfusion, Volume 64, Issue 12, Page 2233-2240, December 2024.
Abstract Background The characteristic feature of immune cytopenias involves the process of extravascular phagocytosis, wherein macrophages in the spleen and/or liver engage in the destruction of blood cells that have been opsonized by auto‐ or alloantibodies.
Melika Loriamini, Melissa M. Lewis‐Bakker, Beth Binnington, Lakshmi P. Kotra, Donald R. Branch   +4 more
wiley   +1 more source

LC–MS‐Based Simultaneous Determination of Biomarkers in Dried Urine Spots for the Detection of Cofactor‐Dependent Metabolic Disorders in Neonates

Journal of Separation Science, Volume 47, Issue 22, November 2024.
ABSTRACT Deficiency of cofactors for various enzymes can lead to inborn errors of metabolism. These conditions frequently occur as seizures, which lead to permanent brain damage. Newborn screening for biomarkers associated with these disorders can help in early detection and treatment.
Arya Raveendran, Ashutosh Gupta, Leslie E. Lewis, Krishnananda Prabhu, Sudheer Moorkoth   +4 more
wiley   +1 more source

Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives

EFSA Journal, Volume 22, Issue 11, November 2024.
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Monika Batke, Ellen Bruzell, James Chipman, Karlien Cheyns, Riccardo Crebelli, Cristina Fortes, Peter Fürst, Thorhallur Halldorsson, Jean‐Charles LeBlanc, Manuela Mirat, Oliver Lindtner, Alicja Mortensen, Evangelia Ntzani, Romina Shah, Heather Wallace, Matthew Wright, Stefania Barmaz, Consuelo Civitella, Petra Georgelova, Federica Lodi, Elena Mazzoli, Josef Rasinger, Ana Maria Rincon, Alexandra Tard, Panagiota Zakidou, Maged Younes   +42 more
wiley   +1 more source

Recent Advances in Genetics of the Spontaneously Hypertensive Rat [PDF]

, 2010
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. Multiple quantitative trait loci associated with hemodynamic and metabolic parameters have been mapped in the ...
Michal Pravenec, Theodore W. Kurtz
core   +3 more sources

Mouse developmental defects, but not paraganglioma tumorigenesis, upon conditional Complex II loss in early Sox10+ cells

FASEB BioAdvances, Volume 6, Issue 9, Page 327-336, September 2024.
In humans, paragangliomas (PGLs) form in certain neuroendocrine cells that have lost succinate dehydrogenase, an enzyme of the tricarboxylic acid cycle. Conditional SDH deficiency has not yet been shown to drive PGL formation in mice, limiting available research tools. Here, prenatal SDH knockout in small numbers of SOX10+ precursors of adrenal medulla
Elizabeth P. Lewis, Fatimah Al Khazal, Brandon Wilbanks, Naomi M. Gades, Patricia Ortega‐Sáenz, José López‐Barneo, Igor Adameyko, L. James Maher III   +7 more
wiley   +1 more source

Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation [PDF]

, 2008
The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance.
Akdis, Benichou, Buiting, Cebon, Csencsits, Dai, Demetris, Demetris, Demetris, Fleisch, Ganta, Gould, Heeger, Huitinga, Ichikawa, Josien, Jurcevic, Ko, Konieczny, Lakkis, Larsen, Lechler, Mellor, Munn, Murase, Murase, Murase, Nakao, Neto, Nikolic, Okuda, Rabinovich, Raisanen-Sokolowski, Sawitzki, Sekine, Sims, Slegers, Smith, Starzl, Starzl, Sun, Talmage, Van Rooijen, Van Rooijen, Van Rooijen, Wu, Yagihashi, Yan, Zhang   +48 more
core   +2 more sources

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

Aging Cell, Volume 23, Issue 9, September 2024.
We tested if the effects of metformin were context specific in skeletal muscle using a rat model (high‐capacity and low‐capacity runners: HCRs/LCRs) with a divide in intrinsic aerobic capacity. Metformin lowered mitochondrial respiration, but a washout of metformin resulted in a doubling of respiratory capacity in HCRs, with no effect in LCRs.
Matthew P. Bubak, Arik Davidyan, Colleen L. O'Reilly, Samim A. Mondal, Jordan Keast, Stephen M. Doidge, Agnieszka K. Borowik, Michael E. Taylor, Evelina Volovičeva, Michael T. Kinter, Steven L. Britton, Lauren G. Koch, Michael B. Stout, Tommy L. Lewis Jr, Benjamin F. Miller   +14 more
wiley   +1 more source

FK506 suppression of heart and liver allograft rejection: II: The induction of graft acceptance in rats [PDF]

, 1990
Lewis recipients of orthotopic ACI livers had permanent graft acceptance induced with 3 doses of i.m. FK506 in the early postoperative period. They were studied 100 and 300 days posttransplantation.
Cramer, DV, Dong-Goo, K, Fung, J, Murase, N, Starzl, TE, Todo, S   +5 more
core   +1 more source

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Animal Models and Experimental Medicine, Volume 7, Issue 3, Page 297-309, June 2024.
Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Yasodha Krishna Janapati, Sunil Junapudi
wiley   +1 more source