Results 31 to 40 of about 16,678 (173)

Long‐Term Safety and Efficacy of Pegvaliase in Japanese Adults With Phenylketonuria: Final Results of a Phase III Trial

open access: yesJIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Phenylketonuria (PKU) is an inborn error of metabolism leading to phenylalanine (Phe) accumulation and consequent neurological, neurocognitive, and psychiatric symptoms. Pegvaliase, a pegylated recombinant phenylalanine ammonia lyase that metabolizes Phe, effectively reduced blood Phe in phase III studies in the United States. This multicenter,
Yoko Nakajima   +6 more
wiley   +1 more source

Estudo da associação entre duas regiões do genoma do rato, localizadas nos cromossomos 4 e 7, e a emocionalidade em duas linhagens de ratos selecionadas no teste do campo aberto [PDF]

open access: yes, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em NeurociênciasAs linhagens de ratos Floripa H e Floripa L, selecionadas bidirecionalmente para extremos de locomoção no centro do ...
Hameister, Thaís Muller
core  

Educational Attainment of Children With Major Congenital Anomalies During Primary School in England: A Population Cohort Study

open access: yesPaediatric and Perinatal Epidemiology, Volume 40, Issue 4, Page 511-525, May 2026.
ABSTRACT Background Major congenital anomalies (CA) affect 2.3% of livebirths and are associated with lower educational attainment. Understanding attainment trajectories throughout primary school would inform parents, schools and organisations and help plan support.
Joachim Tan   +11 more
wiley   +1 more source

Genetic analysis of circadian and ultradian locomotor activity rhythms in laboratory rats [PDF]

open access: yes, 1987
Obvious differences exist in the daily activity patterns of the LEW/Ztm and ACI/Ztm inbred strains of laboratory rats. The inbred strain ACI/Ztm shows a clear 24-h rhythm of locomotor activity.
Wollnik, Franziska   +2 more
core   +1 more source

A Neonatal Nurse‐Controlled Model of Analgesia to Manage Post‐Operative Pain in the Surgical Neonate: A Pilot Randomised Controlled Trial

open access: yesJournal of Advanced Nursing, Volume 82, Issue 2, Page 1725-1736, February 2026.
ABSTRACT Aim To test the feasibility and acceptability of a newly developed model of neonatal nurse‐controlled analgesia to manage pain in the post‐operative infant. Design The study utilised a single‐centre two‐arm parallel, unblinded randomised controlled external pilot trial design.
Renee Muirhead   +5 more
wiley   +1 more source

Respostas comportamentais de nocicepção e ansiedade em duas linhagens de ratos, lewis e SHR, contrastantes para a ansiedade: envolvimento da substância P e dos receptores NK1 [PDF]

open access: yes, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.A ansiedade, ao mesmo tempo em que é influenciada por fatores genéticos, pode modular a reatividade à dor.
Vendruscolo, Leandro Franco
core  

Glucocorticoid negative feedback on the HPA axis in five inbred rat strains

open access: yes, 1998
The aim of the present work was to study the influence of altering glucocorticoid negative feedback on both basal activity of the hypothalamic-pituitary-adrenal (HPA) axis and its response to acute stress (tail shock) in five inbred rat strains known to
E. Ronald De Kloet   +2 more
core   +1 more source

O cromossomo 4 influência comportamentos relacionados à memória em um modelo genético de ratos [PDF]

open access: yes, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2015.Os ratos das linhagens Lewis (LEW) e Spontaneously hypertensive rats (SHR) diferem em uma série
Corrêa, Fernanda Junkes
core  

Maternal Provisioning of Offspring With Defence Chemicals in a Facultatively Parthenogenetic Stick Insect

open access: yesEcology and Evolution, Volume 15, Issue 4, April 2025.
We show that females of the stick‐insect Megacrania batesii transfer defensive alkaloids to their offspring, providing a novel example of maternal provisioning. We also provide evidence that provisioning is enhanced by parthenogenetic reproduction in this species.
Ana Caroline Oliveira Vasconcelos   +2 more
wiley   +1 more source

A novel small molecule phagocytosis inhibitor, KB‐208, ameliorates ITP in mouse models with similar efficacy as IVIG

open access: yesTransfusion, Volume 64, Issue 12, Page 2233-2240, December 2024.
Abstract Background The characteristic feature of immune cytopenias involves the process of extravascular phagocytosis, wherein macrophages in the spleen and/or liver engage in the destruction of blood cells that have been opsonized by auto‐ or alloantibodies.
Melika Loriamini   +4 more
wiley   +1 more source

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