Results 31 to 40 of about 750,094 (133)

A Neonatal Nurse‐Controlled Model of Analgesia to Manage Post‐Operative Pain in the Surgical Neonate: A Pilot Randomised Controlled Trial

open access: yesJournal of Advanced Nursing, Volume 82, Issue 2, Page 1725-1736, February 2026.
ABSTRACT Aim To test the feasibility and acceptability of a newly developed model of neonatal nurse‐controlled analgesia to manage pain in the post‐operative infant. Design The study utilised a single‐centre two‐arm parallel, unblinded randomised controlled external pilot trial design.
Renee Muirhead   +5 more
wiley   +1 more source

Feeding of Celastrus suppresses the induction of adjuvant arthritis (AA) in the Lewis (LEW) rat

open access: yes, 2011
Copyright information:Taken from "Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65"http://arthritis-research.com/content/9/4/R70Arthritis Research & Therapy 2007;9(4):R70-R70 ...
Kamal D Moudgil (84276), Li Tong (84275)
core   +1 more source

Maternal Provisioning of Offspring With Defence Chemicals in a Facultatively Parthenogenetic Stick Insect

open access: yesEcology and Evolution, Volume 15, Issue 4, April 2025.
We show that females of the stick‐insect Megacrania batesii transfer defensive alkaloids to their offspring, providing a novel example of maternal provisioning. We also provide evidence that provisioning is enhanced by parthenogenetic reproduction in this species.
Ana Caroline Oliveira Vasconcelos   +2 more
wiley   +1 more source

A novel small molecule phagocytosis inhibitor, KB‐208, ameliorates ITP in mouse models with similar efficacy as IVIG

open access: yesTransfusion, Volume 64, Issue 12, Page 2233-2240, December 2024.
Abstract Background The characteristic feature of immune cytopenias involves the process of extravascular phagocytosis, wherein macrophages in the spleen and/or liver engage in the destruction of blood cells that have been opsonized by auto‐ or alloantibodies.
Melika Loriamini   +4 more
wiley   +1 more source

Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives

open access: yesEFSA Journal, Volume 22, Issue 11, November 2024.
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF)   +42 more
wiley   +1 more source

Mouse developmental defects, but not paraganglioma tumorigenesis, upon conditional Complex II loss in early Sox10+ cells

open access: yesFASEB BioAdvances, Volume 6, Issue 9, Page 327-336, September 2024.
In humans, paragangliomas (PGLs) form in certain neuroendocrine cells that have lost succinate dehydrogenase, an enzyme of the tricarboxylic acid cycle. Conditional SDH deficiency has not yet been shown to drive PGL formation in mice, limiting available research tools. Here, prenatal SDH knockout in small numbers of SOX10+ precursors of adrenal medulla
Elizabeth P. Lewis   +7 more
wiley   +1 more source

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

open access: yesAging Cell, Volume 23, Issue 9, September 2024.
We tested if the effects of metformin were context specific in skeletal muscle using a rat model (high‐capacity and low‐capacity runners: HCRs/LCRs) with a divide in intrinsic aerobic capacity. Metformin lowered mitochondrial respiration, but a washout of metformin resulted in a doubling of respiratory capacity in HCRs, with no effect in LCRs.
Matthew P. Bubak   +14 more
wiley   +1 more source

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

open access: yesAnimal Models and Experimental Medicine, Volume 7, Issue 3, Page 297-309, June 2024.
Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Yasodha Krishna Janapati, Sunil Junapudi
wiley   +1 more source

Effects of adult or perinatal hormonal environment on ultradian rhythms in locomotor activity of laboratory LEW/Ztm rats [PDF]

open access: yes, 1986
Four experiments were performed with male and female rats of the inbred strain LEW/Ztm maintained under a light-dark schedule of 12:12 hours. The animals were subject to castration (GOX) or ovariectomy (OVX), estradiol 17β-implantation (E2-capsules),
Döhler, Klaus-Dieter   +1 more
core   +1 more source

Tests of evolutionary and genetic rescue using flour beetles, Tribolium castaneum, experimentally evolved to thermal conditions

open access: yesEcology and Evolution, Volume 14, Issue 5, May 2024.
We use experimental evolution to test the effects of demographic and evolutionary rescue in populations of Tribolium castaneum previously adapted to high temperature and kept at small population sizes. We find no evidence of rescue in these populations and discuss the results in the context of conservation intervention.
Rebecca Lewis   +4 more
wiley   +1 more source

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