Results 61 to 70 of about 2,739 (187)

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model [PDF]

, 2016
Endotoxin-induced uveitis (EIU) in rodents is a model of acute Toll-like receptor 4 (TLR4)-mediated organ inflammation, and has been used to model human anterior uveitis, examine leukocyte trafficking and test novel anti-inflammatory therapeutics.
Ali, Robin R, Chu, Colin J, Copland, David A, Dick, Andrew D, Gardner, Peter J, Gonzalez-Cordero, Anai, Kleine Holthaus, Sophia-Martha, Liyanage, Sidath E, Luhmann, Ulrich F O, Smith, Alexander J   +9 more
core   +7 more sources

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Hamann, Jörg, Hoek, Robert M., Huitinga, Inge, Koning, Nathalie, Pouwels, Walter, Raes, Geert, van Eijk, Marco, Voehringer, David   +8 more
core   +1 more source

Suppressive effects of a novel compound on interphotoreceptor retinoid-binding protein-induced experimental autoimmune uveoretinitis in rats

Allergology International, 1999
The immunosuppressive effect of ethyl O-(N-(pcarboxyphenyl)-carbamoyl)-mycophenolate(CAM) was examined in interphotoreceptor retinoid-binding protein (IRBP)-induced experimental autoimmune uveoretinitis (EAU) in rats.
Jun-ichi Sakai, Takeshi Kezuka, Hidetoshi Yokoi, Annabelle A Okada, Masahiko Usui, Junichiro Mizuguchi, Yutaro Kaneko   +6 more
doaj   +1 more source

Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. [PDF]

PLoS ONE, 2012
The small heat shock protein, αA-crystallin null (αA-/-) mice are known to be more prone to retinal degeneration than the wild type mice in Experimental Autoimmune Uveoretinitis (EAU).
Narsing A Rao, Sindhu Saraswathy, Geeta Pararajasegaram, Suraj P Bhat   +3 more
doaj   +1 more source

Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]

, 2018
Funding/Support: No funding or grant support. Financial Disclosures: John V. Forrester has received an honorarium for lecturing from Janssen (London, UK). Lucia Kuffova has undertaken consultancy work for Abbvie (London, UK). Andrew D.
Dick, Andrew D., Forrester, John V., Kuffova, Lucia   +2 more
core   +4 more sources

ISEV2023 Abstract Book

, 2023
Journal of Extracellular Vesicles, Volume 12, Issue S1, May 2023.
wiley   +1 more source

Choroidal mast cells in retinal pathology: a potential target for intervention. [PDF]

, 2015
Mast cells are important in the initiation of ocular inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacterized.
Behar-Cohen, F., Bergin, C., Besson-Lescure, B., Bousquet, E., Castaneda, B., de Kozak, Y., Lorena, V., Naud, M.C., Thillaye-Goldenberg, B., Zhao, M.   +9 more
core   +1 more source

Sialoadhesin Promotes the Inflammatory Response in Experimental Autoimmune Uveoretinitis [PDF]

The Journal of Immunology, 2006
Abstract Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced ...
Hui-Rong, Jiang, Lenias, Hwenda, Kimmo, Makinen, Cornelia, Oetke, Paul R, Crocker, John V, Forrester   +5 more
openaire   +2 more sources

Toxicidade intravítrea da rapamicina em olhos de coelhos [PDF]

, 2009
PURPOSE: To evaluate retinal toxicity of varying doses of rapamycin when injected intravitreally in rabbits. Rapamycin is a potent immunosuppressive agent with significant antitumor and antiangiogenic properties, clinically approved for prevention of ...
CHEVEZ-BARRIOS, Patricia, KHAN, Palwasha, KIVILCIM, Muhamet, MANZANO, Roberta Pereira de Almeida, PEYMAN, Gholam A., TAKAHASHI, Walter   +5 more
core   +2 more sources

CD44 Participates to Extramedullary Haematopoiesis Onset by Mediating the Interplay Between Monocytes and Haematopoietic Stem Cells in Myelofibrosis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Extramedullary haematopoiesis (EMH) refers to blood generation outside of the bone marrow (BM). In Myelofibrosis (MF), a myeloproliferative neoplasm, the disruption of BM microenvironment promotes haematopoietic stem and progenitor cells (HSPCs) mobilisation, resulting in the onset of EMH in the spleen, and then in splenomegaly.
Margherita Mirabile, Camilla Tombari, Anita Neroni, Lara Tavernari, Ruggiero Norfo, Elisa Bianchi, Monica Maccaferri, Barbara Mora, Sandra Parenti, Chiara Carretta, Matteo Bertesi, Marica Malerba, Elisa Papa, Luca Fabbiani, Niccolò Bartalucci, Paola Guglielmelli, Leonardo Potenza, Lorena Losi, Francesco Passamonti, Enrico Tagliafico, Mario Luppi, Sebastiano Rontauroli, Alessandro Maria Vannucchi, Rossella Manfredini, on behalf of the MYNERVA (Myeloid NEoplasms Research Venture AIRC) investigators   +24 more
wiley   +1 more source