Results 61 to 70 of about 1,555 (179)

Spontaneous development of autoimmune uveoretinitis in nude mice following reconstitution with embryonic rat thymus

, 1991
SUMMARY This paper describes the spontaneous occurrence of an autoimmune uveoretinitis in nude (nu/nu) mice reconstituted when 4 weeks old by the grafting of rat embryonic thymus.
O TAGUCH, T TAKAHASHI, Y NISHIZUKA, T ICHIKAWA, M TAKEUCHI, M- USUI, H IKEDA, T TANAKA   +7 more
core   +1 more source

Mechanisms for inducing nasal mucosal tolerance in Experimental Autoimmune Uveoretinitis (EAU)

, 2006
Delivering soluble (auto) antigenic peptides via the naso-respiratory route induces tolerance to that peptide and suppression of experimental models of autoimmune disease.
Dick, AD, Andrew D. Dick, Calder, CJ, Lindsay B. Nicholson, Claudia J. Calder, Nicholson, LB   +5 more
core   +1 more source

Gene therapy and bone marrow transplantation for treatment of experimental autoimmune uveoretinitis

, 2017
Uveitis is the fourth leading cause of blindness in the working age population in developed countries and endogenous posterior uveoretinitis makes up 22% of the uveitis cases. The aetiology of non-infectious uveoretinitis is unknown in most cases and has
Chen, Xiangting (3802744)
core   +1 more source

Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA [PDF]

, 2010
Osteopontin (OPN) is elevated during the progression of experimental autoimmune uveoretinitis (EAU) in C57BL/6 (B6) mice. Furthermore, EAU symptoms are ameliorated in OPN knockout mice or in B6 mice treated with anti-OPN antibody (M5).
Uede, Toshimitsu, Kitamura, Mizuki, Kitaichi, Nobuyoshi, Saito, Yoshinari, Morimoto, Junko, Kon, Shigeyuki, Yoshida, Kazuhiko, Ohno, Shigeaki, Namba, Kenichi, Ebihara, Akiko, Iwabuchi, Kazuya, Onoé, Kazunori, Iwata, Daiju, Ishida, Susumu, Kitamei, Hirokuni   +14 more
core   +1 more source

Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis.

PLoS ONE, 2023
PurposeAngiopoietin (Ang) 2 is released from vascular endothelial cells by the stimulation of vascular endothelial growth factor (VEGF)A. Ang2 increases the expression of leukocyte adhesion molecules on endothelial cells via nuclear factor κB. The aim of
Kayo Suzuki, Daiju Iwata, Kenichi Namba, Keitaro Hase, Miki Hiraoka, Miyuki Murata, Nobuyoshi Kitaichi, Richard Foxton, Susumu Ishida   +8 more
doaj   +1 more source

CD44 Participates to Extramedullary Haematopoiesis Onset by Mediating the Interplay Between Monocytes and Haematopoietic Stem Cells in Myelofibrosis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Extramedullary haematopoiesis (EMH) refers to blood generation outside of the bone marrow (BM). In Myelofibrosis (MF), a myeloproliferative neoplasm, the disruption of BM microenvironment promotes haematopoietic stem and progenitor cells (HSPCs) mobilisation, resulting in the onset of EMH in the spleen, and then in splenomegaly.
Margherita Mirabile, Camilla Tombari, Anita Neroni, Lara Tavernari, Ruggiero Norfo, Elisa Bianchi, Monica Maccaferri, Barbara Mora, Sandra Parenti, Chiara Carretta, Matteo Bertesi, Marica Malerba, Elisa Papa, Luca Fabbiani, Niccolò Bartalucci, Paola Guglielmelli, Leonardo Potenza, Lorena Losi, Francesco Passamonti, Enrico Tagliafico, Mario Luppi, Sebastiano Rontauroli, Alessandro Maria Vannucchi, Rossella Manfredini, on behalf of the MYNERVA (Myeloid NEoplasms Research Venture AIRC) investigators   +24 more
wiley   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, Volume 12, Issue 24, June 26, 2025.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Volume 94, Issue 1, Page 257-414, February 2024.
Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases ...
Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang   +3 more
wiley   +1 more source

Choroidal mast cell dynamics during experimental autoimmune uveoretinitis in rat strains of differing susceptibility

, 1994
Choroidal mast cells have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). The aim of the present study was to examine the dynamics of choroidal mast cells during the course of EAU in rat strains of varying ...
Mcmenamin, C., R. J. Steptoe, Steptoe, R. J., P. G. McMenamin, Mcmenamin, P. G., C. McMenamin   +5 more
core   +1 more source

Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental Mouse Model

Investigative Opthalmology & Visual Science, 2017
To accurately evaluate the autoimmune inflammation, we aim to develop three quantitative measurements to monitor the inflammatory changes in the retina: retinal-choroidal thickness, major retinal vessel diameter, and electroretinography amplitudes.During a 21-day experimental period, eyes were examined by confocal scanning laser ophthalmoscopy, optical
Jian, Li, Jialin, Ren, Yolanda Wong Ying, Yip, Xiaoyu, Zhang, Kai On, Chu, Tsz Kin, Ng, Sun On, Chan, Chi Pui, Pang, Wai Kit, Chu   +8 more
openaire   +2 more sources