Results 81 to 90 of about 2,739 (187)
Development of Clarstatin, a Novel Drug Lead for the Therapy of Autoimmune Uveitis
PharmaceuticsWe describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid sequence (Q/D)1-(R/K)2-X3-X4-A5-(Gln/Asp)1-(Arg/Lys)2-AA3-AA4-Ala5-based on a motif called “shared ...
Shira Merzbach +4 more
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Immunomodulation by mesenchymal stem cells: interplay between mesenchymal stem cells and regulatory lymphocytes [PDF]
, 2016 published_or_final_versio
Chan, KH, Ma, KFO
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PLoS ONE, 2013 Experimental autoimmune uveoretinitis (EAU) in mice is a model for human autoimmune uveitis. Longitudinal follow-up is only possible by non-invasive techniques, but the information obtained by visual fundus examination can be limited.
Jun Chen +4 more
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Corticosteroid implants for chronic non-infectious uveitis. [PDF]
, 2016 BACKGROUND: Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid).
Brady, Christopher J +7 more
core +2 more sources
, 2013 Histopathology has initially been and is still used to diagnose infectious, degenerative or neoplastic diseases in humans or animals. In addition to qualitative diagnoses semiquantitative scoring of a lesion`s magnitude on an ordinal scale is a commonly ...
Klopfleisch, Robert
core +1 more source
Frontiers in Immunology, 2018 Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid cells, have gained increasing attention for their role in the fine tuning of both innate and adaptive immunity.
Elise Chiffoleau +3 more
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CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease [PDF]
, 2011 Background Increasing evidence suggests that microglial activation may participate in the aetiology and pathogenesis of Parkinson's disease (PD). CD200-CD200R signalling has been shown to be critical for restraining microglial activation.
Shi Zhang +7 more
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Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis
Scientific Reports, 2017 We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. Recently, MSC-derived exosomes (MSC-Exo) were thought to carry functions of MSCs.
Lingling Bai +9 more
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Notch Signaling and T-Helper Cells in EAE/MS [PDF]
, 2013 The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Bassil, Ribal +2 more
core +3 more sources
International Journal of Nanomedicine, 2022 Zhangluxi Liu, Jing Xu, Hongxi Li, Jia Shu, Guannan Su, Chunjiang Zhou, Peizeng Yang The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical ...
Liu Z +6 more
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