Results 1 to 10 of about 441,178 (207)
PLoS Neglected Tropical Diseases, 2010 Infection by Leptospira interrogans has been causally associated with human and equine uveitis. Studies in our laboratories have demonstrated that leptospiral lipoprotein LruA and LruB are expressed in the eyes of uveitic horses, and that antibodies ...
Brian Stevenson
exaly +3 more sources
Chronic environmental temperature affects protein expression in the eye of adult zebrafish (Danio rerio) [PDF]
Scientific ReportsVision in vertebrates is mediated by the eye, a complex organ with developmental and functional similarities to the central nervous system. Eye proteomics has emerged as a powerful tool for investigating ocular function and disease mechanisms, including ...
Elisa Maffioli +7 more
doaj +2 more sources
Development of Autologous Serum Ocular Insert for Chronic Dry Eye Disease [PDF]
PharmaceuticsBackground: Dry eye disease is a multifactorial disease of the ocular surface and/or tear film. It is one of the leading causes of ocular morbidity worldwide.
Hend Abdelmohsen +3 more
doaj +2 more sources
Glycation of nail proteins: from basic biochemical findings to a representative marker for diabetic glycation-associated target organ damage. [PDF]
PLoS ONE, 2015 Although assessment of glycated nail proteins may be a useful marker for monitoring of diabetes, their nature and formation are still poorly understood. Besides a detailed anatomical analysis of keratin glycation, the usefulness of glycated nail protein ...
Antoine Sadiki Kishabongo +7 more
doaj +1 more source
Keeping an eye on SOXC proteins [PDF]
Developmental Dynamics, 2014 The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate.
Lakshmi, Pillai-Kastoori +2 more
openaire +2 more sources
The use of in-strip digestion for fast proteomic analysis on tear fluid from dry eye patients. [PDF]
PLoS ONE, 2018 Tear is an accessible fluid for exploring biomarkers of dry eye disease. This study describes a fast proteomic method by LC-Q-orbitrap-MS analysis with in-strip digestion and investigates the tear proteome of dry eye patients. Schirmer's strips were used
Zhu Huang, Chi-Xin Du, Xiao-Dong Pan
doaj +1 more source
Profiling tear proteomes of patients with unilateral relapsed Behcet’s disease-associated uveitis using data-independent acquisition proteomics [PDF]
PeerJ, 2020 Purpose To explore whether unilateral relapse of Bechet’s disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers for uveitis recurrence and disease ...
Anyi Liang +5 more
doaj +2 more sources
Region-resolved multi-omics of the mouse eye
Cell Reports, 2023 Summary: The eye is a complex organ consisting of multiple compartments with unique and specialized properties, and small disturbances in one eye region can result in impaired vision and blindness. Although there have been advancements in ocular research,
Hang Xiang +7 more
doaj +1 more source
Metallothioneins, a Part of the Retinal Endogenous Protective System in Various Ocular Diseases
Antioxidants, 2023 Metallothioneins are the metal-rich proteins that play important roles in metal homeostasis and detoxification. Moreover, these proteins protect cells against oxidative stress, inhibit proapoptotic mechanisms and enhance cell differentiation and survival.
Daniel Jamrozik +5 more
doaj +1 more source
The multi-functional eyes absent proteins [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2020 The Eyes Absent (EYA) proteins are the only known instance of a single polypeptide housing the following three separable biochemical activities: tyrosine phosphatase, threonine phosphatase, and transactivation. This uniquely positions the EYAs to participate in both transcriptional regulation and signal transduction pathways.
Rashmi S. Hegde +2 more
openaire +2 more sources